1 / 28

Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes

Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells VEGF, Notch. Vasculogesis and angiogenesis in vertebrates. Models Intussuseptive angiogenesis

onawa
Download Presentation

Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells VEGF, Notch

  2. Vasculogesis and angiogenesis in vertebrates

  3. Models Intussuseptive angiogenesis (tissues as muscle, often blood flow dependent etc.)

  4. Angiogenesis is a dynamic and context determined process

  5. Examples of vascular defects

  6. Integrins in the vasculature

  7. L1CAM A7 Lm 68% embryonic lethal hemorrgaged E10-14.5 SM cells

  8. Integrin inhibitors and RTK agonistic interactions (Kaan)

  9. Angiopoitins, Tie1 and Tie2 receptor

  10. PDGF RTK signaling

  11. VEGF RTK signaling

  12. VEGFR3 at tips cells

  13. Signaling in sprouting tip cells

  14. Delta-Notch signaling

  15. semaphorins Sema3 inhibits integrin function. Normal angiogenesis…

  16. Mouse models affecting TGFbeta signaling

  17. Haemodynamics affect vascular remodelling example

  18. Pixt2 KO phenotypes in 6th BAA Occlusion of right BAAs results in Persistence of left 6 BAA

More Related