MOLECULAR TARGETS: Drug Design & Diagnostics for the 21 st Century

1. The Institute for Molecular Diversity & Drug Design Symposium 2008 MOLECULAR TARGETS:Drug Design & Diagnostics for the 21st Century Hank Wagner Conference CenterJewish Hospital HealthCare Services 200 Abraham Flexner Way Tuesday, March 11, 20088:00 AM – 2:00 PM Please contact Sarah Andres (sarah.andres@louisville.edu) to register at no charge for the conference and reception. Distinguished Visiting Speakers: Featured Speakers from the IMD3: Laurence Hurley – Dr. Hurley, widely respected for his innovative research and inventions on the design and development of anti-tumor agents, is the Howard J. Schaeffer Professor of Pharmaceutical Sciences at the University of Arizona. After Honors studies at Bath University in the UK, he received a Ph.D. in medicinal chemistry from Purdue University. Recent research focuses on secondary DNA structures, particularly G-quadruplexes, as gene targets for drug design. His many honors include the George Hitchings Award for Innovative Methods in Drug Design and the Volwiler Research Achievement Award. In 2007, Dr. Hurley was inducted into the American Chemical Society Medicinal Chemistry Hall of Fame. Denis Kinane - Dr. Kinane completed his dental education and Ph.D. at the University of Edinburgh with Fellowships from both Edinburgh and Glasgow Royal Colleges. Denis, widely regarded for his creative approaches, is Associate Dean for Research and Delta Dental Endowed Professor of Periodontology and Professor of Immunology. He leads a comprehensive research group on Oral Health and Systemic Disease focusing on periodontal immune and inflammatory processes, to explain causes, development and susceptibility markers of periodontal disease. His internationally regarded research team brings a unique perspective to IMD3, as they examinine relationships between oral and systemic health, and other diseases such as diabetes, cardiovascular disease and periodontal disease. Eugene Mueller - Dr. Mueller is the newly appointed Charles L. Bloch Professor of Chemistry. Eugene graduated in Chemistry with Honors from the University of Illinois and completed a Ph. D. degree from Harvard University in biochemistry, addressing mechanistic enzymology. His research with 4-thiouridine generation provided a paradigm for sulfur transfer using persulfide groups. Eugene’s original labeling studies with oxygen18-labeled water allowed reassessment of the pseudouridine formation process and provided information related to mechanisms for sulfur placement into many molecules in the cell. There is no question that he will play an important role as an creative investigator and teacher in the IMD3. Philip Low - Dr. Low is the Ralph C. Corley Distinguished Professor of Chemistry at Purdue University and the founder of Endocyte Inc. After graduate studies in Biochemistry at University of California, San Diego, he developed an acclaimed research group investigating structure/function relationships of human erythrocyte membranes and developing receptor-targeted imaging and therapeutic agents for cancer and inflammatory diseases. Dr. Low has served on numerous NIH Study Sections and has received an NIH MERIT Award. Well regarded as a superb teacher, he received both of Purdue University's awards for Outstanding Research and guided the discovery and development of five drugs currently in clinical trials. Department of Biochemistry & Molecular Biology Hormone Receptor Laboratory