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Migraine Visual Aura

932-5. Migraine Visual Aura. Pathophysiology.

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Migraine Visual Aura

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  1. 932-5 Migraine Visual Aura

  2. Pathophysiology The pain of migraine headache is thought to have a neurogenic basis. Migraine involves dysfunction of brain-stem pathways that normally modulate sensory input.The key pathways for the pain are the trigeminovascular input from the meningeal vessels, which passes through the trigeminal ganglion and synapses on second order neurons in the trigeminocervical complex.

  3. Figure 1. Pathophysiology of Migraine.

  4. Pathophysiology These neurons, in turn, project through the quintothalamic tract, and after decussating in the brainstem, form synapses with neurons in the thalamus.

  5. Pathophysiology There is a reflex connection between neurons in the pons in the superior salivatory nucleus, which results in a cranial parasympathetic outflow that is mediated through the pterygopalatine, otic, and carotid ganglia.

  6. Pathophysiology This trigeminal–autonomic reflex is present in normal persons and is expressed most strongly in patients with trigeminal–autonomic cephalgias, such as cluster headache and paroxysmal hemicrania.

  7. Pathophysiology Brain imaging studies suggest that important modulation of the trigeminovascular nociceptive input comes from the dorsal raphe nucleus, locus ceruleus, and nucleus raphe magnus. Goadsby PJ, Lipton RB, Ferrari MD. Migraine – Current understanding and treatment. N Engl J Med Jan 1, 2002; 346 (4):257-270.

  8. Figure 2. Possible Sites of Action of Triptans in the Trigeminovascular System.

  9. Acknowledgement Figures 1, 2 published Courtesy of PJ Goadsby, M.D DSc Goadsby PJ, Lipton RB, Ferrari MD. Migraine – Current understanding and treatment. N Engl J Med 2002, 346 (4): 257-270.

  10. http://library.med.utah.edu/NOVEL/Wray/

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