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Translating Research into Practice: Making Today’s Goals Tomorrow’s Reality

Translating Research into Practice: Making Today’s Goals Tomorrow’s Reality. Carolyn Clancy, M.D. Director Agency for Healthcare Research and Quality Oregon Health & Science University Grand Rounds Portland – January 14, 2008. Excellence & Mediocrity.

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Translating Research into Practice: Making Today’s Goals Tomorrow’s Reality

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  1. Translating Research into Practice: Making Today’s Goals Tomorrow’s Reality Carolyn Clancy, M.D. Director Agency for Healthcare Research and Quality Oregon Health & Science University Grand Rounds Portland – January 14, 2008

  2. Excellence & Mediocrity “A society which scorns excellence in plumbing simply because it is plumbing, but rewards mediocre philosophy simply because it is philosophy will soon become a society in which neither its pipes nor its theories will hold water.” John W. Gardner (1961)

  3. ‘Consider This Recent Case’

  4. Social Workers Disease Management Patients Nurses Physicians Medical Home PHRs Family & Care Givers Care Managers Coordination of Care

  5. Making Today’s Goals Tomorrow’s Reality • Turning Evidence Into Action: AHRQ Resources and Priorities • Comparative Effectiveness: Effective Health Care • Current and Future Directions for Health IT • 21st Century Health Care • Q&A

  6. AHRQ’s Mission Improve the quality, safety, efficiency and effectiveness of health care for all Americans

  7. FY 2008 Funding • $334.6 million • FY 2008 Request – $329.6 million • FY 2007 Appropriation – $318.7 million • FY 2008 appropriation includes: • $30 million for comparative effectiveness research • Double the $15 million designated in FY 2007 • $5 million for research and activities to reduce Methicillin Resistant Staphylococcus aureus (MRSA) and related infections • The first such federal grant to AHRQ for MRSA/HAIs • Congress also encouraged AHRQ to: • Consider proposals to detect medical errors and preemptively control injury via compact medical devices • Investigate the feasibility of an open-source, no-cost license computer model capable of predicting the effects of health care policy alternatives to improve quality and cost-effectiveness

  8. FY 2008 Priorities Patient Safety • Health IT • Patient SafetyOrganizations • New PatientSafety Grants Effective HealthCare Program AmbulatoryPatient Safety • Comparative Effectiveness • Network of Research Centers • Clear Findings for Multiple Audiences • Safety & Quality Measures,Drug Management andPatient-Centered Care • Patient Safety ImprovementCorps Other Research & Dissemination Activities Medical ExpenditurePanel Surveys • Visit-Level Information on Medical Expenditures • Annual Quality & Disparities Reports • Quality & Cost-Effectiveness, e.g.Prevention and PharmaceuticalOutcomes • U.S. Preventive ServicesTask Force • MRSA/HAIs

  9. AHRQ is funding a Randomized Control Trial to clarify the added value of genetic testing to improve warfarin dosing. AHRQ is funding a DEcIDE project to review databases focusing on utilization and outcomes ofgene-based tests and therapies EPC Reports: The Promise of Genomics: Recent Activities • Genomic testing in ovarian cancer (completed) • CYP450 testing in depression (completed) • HNPCC testing in colorectal patients (completed) • Horizon scan on cancer genetic tests for CMS (completed) • BRCA testing in breast and ovarian cancers (w/USPSTF recommendation) • HER-2-Neu testing in breast cancer (ongoing) • Expression profile tests in breast cancer (ongoing) • Family history in breast, ovarian, colorectal and prostate cancers (ongoing) • Screening for hemochromatosis (w/USPSTF recommendation)

  10. Patient Involvement Campaign • AHRQ’s campaign with the Ad Council uses a series of TV, radio and print public service announcements • Web site features a “Question Builder” for patients to enhance their medical appointments • www.ahrq.gov/questionsaretheanwser

  11. Transforming Hospitals: Designing for Safety and Quality • A DVD that demonstrates how evidence-based design can improve the quality and safety of hospital services while improving staff satisfaction and retention. • Case studies of three hospitals illustrate the benefit of incorporating evidence-based design principles into new construction or renovation projects. http://www.ahrq.gov/qual/transform.htm

  12. AHRQ’s National Reports on Quality and Disparities • 2007 editions pending • New efficiency chapter • Disability data added • More on health literacy

  13. 2006 National Reports – The Good News • Good (but not perfect) news • 6% of patients reported communication problems with doctors* • 7% of patients reported communication problems with nurses *CAHPS Hospital Survey, 2006 National Healthcare Disparities Report

  14. =Most Recent Year = Baseline Year Oregon: Overall Care Quality vs. All States, One-Year Performance Change Average Weak Strong Very Weak Very Strong Performance Meter 2006 National Healthcare Quality Report, State Snapshots

  15. Oregon Snapshot National Healthcare Quality Report, State Snapshots, 2006

  16. Making Today’s Goals Tomorrow’s Reality • Turning Evidence Into Action: AHRQ Resources and Priorities • Comparative Effectiveness: Effective Health Care • Current and Future Directions for Health IT • 21st Century Health Care • Q&A

  17. Comparative Effectiveness:Effective Health Care Program • Uses current, unbiased evidence in making head-to-head comparisons to show which health interventions: • Add Value • Offer minimal benefit above current choices • Fail to reach their potential • Work for some patients, but not others • Builds on years of experience gained through AHRQ’s Evidence-based Practice Centers Goal: to develop and disseminate better evidence about benefits and risks of alternative choices

  18. CERTs Centers NEW

  19. U of Pennsylvania Philadelphia, PA U of Illinois Chicago Johns Hopkins Baltimore, MD Brigham & Women’s Hospital Boston, MA Outcome Science Cambridge, MA Harvard Pilgrim Boston, MA U of Maryland Baltimore, MD Acumen, LLC Palo alto, CA Duke University Durham, NC U of Colorado Aurora, CO RTI International RTP, NC U of North Carolina Chapel Hill, NC Vanderbilt U Nashville, TN DEcIDE Research Network Network of institutions and partner organizations with access to de-identified data of some 50 million patients

  20. Evidence-Based Practice Centers AHRQ Created the EPC Program in 1997 • Promote evidence-based practice and decision-making • Generate comparative effectiveness reviews on medications, devices and other interventions • User-driven, with public and private-sector partners • Blue Cross and Blue Shield Association, Technology Evaluation Center (TEC), Chicago, IL • Duke University, Durham, NC • ECRI, Plymouth Meeting, PA • Johns Hopkins University, Baltimore, MD • McMaster University, Hamilton, Ontario • Oregon Evidence-Based Practice Center • RTI International-University of North Carolina at Chapel Hill, NC • Southern California Evidence-based Practice Center-RAND, Santa Monica, CA • Tufts University-New England Medical Center, Boston, MA • University of Alberta • University of Connecticut • Minnesota Evidence-based Practice Center • University of Ottawa • Vanderbilt University

  21. Effective Health Care Program: Reviews to Date • Nine comparative effectiveness reviews released to date, including: • ACEIs or ARBS: These two common classes of blood pressure pills are equally effective at controlling high blood pressure, November 2007 • PCI vs. CABG: Bypass surgery is more likely than balloon angioplasty (with or without a stent) to bring relief from angina in patients with mid-range coronary artery disease, October 2007 All reviews available at: effectivehealthcare.ahrq.gov

  22. Oregon Evidence-based Practice Center • The Center supports The Guide to Clinical Preventive Services: Recommendations of the U.S. Preventive Services Task Force by preparing systematic evidence reviews and evidence summaries as resources on topics under consideration by the Task Force

  23. Emerging Methods in Comparative Effectiveness & Safety • A series of 23 articles by AHRQ researchers on new approaches in comparative effectiveness methods are compiled in a special October edition of Medical Care • A valuable new resource for scientists committed to advancing the comparative effectiveness and safety research • The Resource Center in Oregon led the development process, helped draft the document and manage work groups, and handled public comment DEcIDE programhttp://effectivehealthcare.ahrq.gov/reports/med-care-report.cfm

  24. Eisenberg Clinical Decisions and Communications Center • The knowledge is used to maximize the benefits of health care, minimize harm and optimize the use of health care resources • Presents evidence synthesized by the Evidence-Based Practice Centers and generated by the DeCIDE Network in actionable formats for stakeholders including patients, providers, policymakers and the public Oregon Health & Sciences University

  25. Program Outputs Research Reports Consumer Guides Systematic Reviews

  26. Findings published January ‘08 in Medical Care show a “concerning association” between privately insured parents and uninsured children Overall, the findings suggest that even when parents successfully gain employment with private health coverage and raise their families out of poverty, health care for their children remains out of reach A study of how gaps in health insurance coverage for low-income Oregon children affect their medical, prescription and dental health The findings are scheduled to be published in the March/April issue of Ambulatory Pediatrics AHRQ Research from the Grants On-line Database (GOLD) Oregon Health & Science University

  27. Making Today’s Goals Tomorrow’s Reality • Turning Evidence Into Action: AHRQ Resources and Priorities • Comparative Effectiveness: Effective Health Care • Current and Future Directions for Health IT • 21st Century Health Care • Q&A

  28. Health IT: Where We’ve Been; Where We’re Going • Long-term agency priority • Since 2004, AHRQ has supported about 200 projects and demonstrations to improve the safety, quality and efficiency of health care in virtually every state • Special attention to best practices that can improve quality of care in rural, small community, safety net and community health center care settings • New focus on ambulatory safety and quality AHRQ Health IT Investment: $216 Million

  29. Ambulatory Safety and Quality Program (ASQ) • Over 60 Grants (in 29 states and the District of Columbia) and Task Orders in 3 areas: • Enabling Quality Measurement through Health IT • Improving Quality through Clinician Use of Health IT • Enabling Patient-Centered Care through Health IT • Health IT CERT awarded to Brigham & Women’s • EPC Report on the Elderly, Chronically Ill and Underserved’s use of health IT • Consumer Engagement Focus Groups • Contract for Technical Assistance for Medicaid and SCHIP programs

  30. Using Precision Performance Measurement to Conduct Focused Quality Improvement – Northwestern University Type of health IT: Quality of Care Decision Support, Vocabulary/Coding Standards Designed to create systems that improve quality data and seamlessly link it to practice-level quality improvement programs and point of care interventions Impact of Health IT on Outcomes in Ambulatory Settings and Across High-Risk Transitions of Care • Estimated Total Funding – $1.2 million • Project Start – Sept. 30, 2007 • Project End – Sept. 29, 2010

  31. The Relationship Between Health IT and Workflow Design • Medication Safety in Primary Care Practice: Translating Research into Practice – Medical University of South Carolina • The project will develop a set of medication safety measures relevant for primary care, incorporate them in quarterly practice performance reports and assess the impact of the intervention on the incidence of medication errors • Type of Health IT: Quality of Care Decision Support Estimated Total Funding: $1.2 million Project Start – Sept. 30, 2007 Project End – Sept. 29, 2010

  32. Oregon Health & Science University Care for Patients with Multiple Chronic Conditions • RxSafe: Shared Medication Management and Decision Support for Rural Clinicians – Oregon Health & Science University • Oregon Health & Science University is using previously developed technology to support shared medication management for persons with chronic conditions. • Type of Health IT: Clinical/Operational Decision Support (provider-focused) Estimated Total Funding: $1.2 million Project Start – Sept. 30, 2007 Project End – Sept. 29, 2010

  33. Women • Harnessing Health IT to Prevent Medication-Induced Birth Defects – University of Pittsburgh • This project will develop and evaluate ways computers may be able to help doctors counsel women about preventing birth defects caused by use of certain medications. • Type of Health IT: Clinical Decision Support (provider-focused), Human/Machine Interface Estimated Total Funding: $1.19 million Project Start – Sept. 30, 2007 Project End – Sept. 29, 2010

  34. Chronic Illness • The BLUES Project: Improving Diabetes Outcomes in Mississippi with Health IT – Delta Health Alliance, Jackson, MS • Demonstrating the effects of diabetes management practices at several ambulatory clinics throughout Mississippi when utilizing well-designed, comprehensive health IT • Type of Health IT: Electronic Medical Record Estimated Total Funding: $1.16 million Project Start – Sept. 30, 2007 Project End – Sept. 29, 2010

  35. Automating Assessment of Asthma Car Quality – Kaiser Foundation Research Institute Type of Health IT: Quality of care decision support, data electronic transform & load Estimated total funding: $871,711 from 9/30/2007 – 9/29/2009 Improving Quality in Cancer Screening: The Excellence Report for Colonoscopy – Oregon Health & Science University Type of Health IT: Operational decision support – quality of care Estimated total funding: $616,207 from 9/30/2007 – 9/29/2009 Other ASQ Grants in Oregon

  36. New ASQ RFA • AHRQ has published an RFA soliciting research projects that focus on using health IT to improve the quality of management for people with complex health care needs • Application deadline of February 21 for submissions that address linkages across service providers, as well as those that focus on the affected individual • Tools and processes to be implemented in a variety of settings, including small and rural practices, in a cost-effective manner • Projects may be funded for a period of up to three years • $3M in funding, approx. 8-10 awards

  37. Making Today’s Goals Tomorrow’s Reality • Turning Evidence Into Action: AHRQ Resources and Priorities • Comparative Effectiveness: Effective Health Care • Current and Future Directions for Health IT • 21st Century Health Care • Q&A

  38. Getting to Value-Driven Health Care “The mantra of competition based on value is that there is no such thing as a national health care market. What we have is a network of local markets." Michael O. Leavitt, Secretary US Dept. of Health and Human Services November 5, 2007

  39. Quality Standards Design systems to collect quality of care information and define what constitutes quality health care Incentives Reward those who provide and purchase high-quality and competitively priced health care Price Standards Aggregate claims information to enable cost comparisons between specific doctors and hospitals Interoperability Set common technical standards for quick and secure communication and data exchange Cornerstones of Value-Driven Health Care

  40. Value-Driven Health Care: Core Principles • All healthcare is local • Broad access to information will improve value by: • stimulating provider improvement • engaging consumers in provider selection, treatment choices • enabling purchasers to align consumer, provider incentives • Nationwide learning network will foster market-based health care reform

  41. Value-Driven Health Care and Health IT • How does Health IT affect patient safety culture? • Adopting and using Health IT remains a huge cultural change for many clinicians • Change requires commitment to achieving and sustaining evolution in culture

  42. What’s Missing in Health Care • Delivery System Design • Real-time information • Clinical effectiveness • Delivery to patients • Impact on patients • Evidence-based management • Shared attention to data • Shared strategies for improvement • Policy adjustments for improvement

  43. Comparative effectiveness information can help establish the value of medicines, procedures and services It can also stimulate the development of important advances in health care, and enhance value and transparency Better comparative information will not address issues such as aging populations and increases in chronic disease Studies could be used to limit treatment options rather than help target the right treatments to the right patients Growing Demand for Comparative Information Potential Benefits Potential Drawbacks

  44. How Can We Enhance Our Efforts? The Evolution of Translational Research

  45. The Social Case: Potential lives saved through quality improvement Woolf and Johnson,

  46. 21st Century Health Care Improving quality by promoting a culture of safety through Value-Driven Health Care Information-rich, patient-focused enterprises Information and evidence transform interactions from reactive to proactive (benefits and harms) Evidence is continually refined as a by-product of care delivery 21st Century Health Care Actionable information available – to clinicians AND patients – “just in time”

  47. A robust health care system must include capacity for: Rapid translation of beneficial advances or breakthroughs Connectivity with the biomedical enterprise Connecting ‘Achievability’ and Reliability… Achievability: What can work under ideal circumstances for some people Reliability: Getting it right for all patients every time – the first time

  48. Making Today’s Goals Tomorrow’s Reality • Turning Evidence Into Action: AHRQ Resources and Priorities • Comparative Effectiveness: Effective Health Care • Current and Future Directions for Health IT • 21st Century Health Care • Q&A

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