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Cancer Biology Valdemar Máximo

Perturbações do metabolismo e desdiferenciação celular no cancro. Cancer Biology Valdemar Máximo. Efeito de Warburg. Glicólise OXPHOS Mesmo na presença de O 2. Adaptado de Vander Heiden MG et al. Science (2009). Efeito de Pasteur Efeito de Warburg.

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Cancer Biology Valdemar Máximo

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  1. Perturbações do metabolismo e desdiferenciação celular no cancro. Cancer Biology Valdemar Máximo

  2. Efeito de Warburg • Glicólise • OXPHOS Mesmo na presença de O2

  3. Adaptado de Vander Heiden MG et al. Science (2009)

  4. Efeito de Pasteur Efeito de Warburg Nâo-fixo Fixo Adaptado de Vander Heiden MG et al. Science (2009)

  5. Adaptado de DeBerardinis RJ et al. Genet Med. (2008)

  6. OXPHOS

  7. mtDNA

  8. nDNA (SDHx)

  9. Br J Cancer, 2005 • nDNA (GRIM-19)

  10. Transfection control Transfection control siRNA control siRNA control Cell control GRIM II Cell control GRIM II GRIM-19 SiRNA GRIM-19 Hk2 GLUT1 Actin 24 hours 48 hours

  11. Mitotracker/Tubulin • Mitotracker/Actin siRNA control (200nM) GRIM II (200nM) siRNA control (200nM) GRIM II (200nM) 24 hours 48 hours • Morfologia GRIM II (200nM)

  12. Conclusão OXPHOS OXPHOS Adaptado de DeBerardinis RJ et al. Genet Med. (2008)

  13. Agradecimentos Grupo Cancer Biology Jorge Lima Paula Soares Manuel Sobrinho-Simões

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