Pharmacy Group Birla Institute of Technology Science Pilani

1. 1 Pharmacy GroupBirla Institute of Technology & SciencePilani

3. About the Group One of the earliest schools of Pharmacy Education and Research (1950) Mission: Producing self-motivated and self reliant young pharmacists catering to the needs of Industry, Academia and Research Programmes Offered: Bachelor of Pharmacy (Hons.) Duration: 4 years Intake:40 Master of Pharmacy: Duration: 2 years ( 4 semesters ) 12-15 every semester (37 on rolls) Doctor of Philosophy: Duration: Minimum 3 years (40 units) Full time research scholars- 12 Faculty - 6

4. Special features of the Programmes Strong exposure to basic science, humanities, management and engineering related subjects Exhaustive exposure to various practical aspects of the research methodologies, instrumental techniques and industrial operations Option for doing projects (Study/ Laboratory/ Computer oriented)from third year onwards along with regular courses, seminars, assignments etc. Unique option for choosing elective towards a specific career path Eight months Practice School (PS-I of 2 months and PS-II of 6 months)/ Thesis option under University – Industry linkage programs Designed with the view of over all development rather than single area specialization Clinical, Industrial, Research, Regulatory Affairs, Management oriented syllabi Courses to develop communication skills and personality

5. University-Industry Linkages Pioneers in Practice School concept (1973); PS-I and PS-II Functional at several National and International Industries and Research Organizations Industries: Concept Pharmaceuticals Ltd, Aurangabad. Cadila Pharmaceuticals Ltd., Ahmedabad Torrent Research Centre, Ahmedabad Novartis Enterprises Pvt Ltd., Mumbai Dr. Reddy’s Lab., Hyderabad Dr. Morepan Labs, Chandigarh IPCA Labs, Mumbai Merind, Mumbai Srides Arcolabs, Bangalore Governmental and Other Agencies: CDRI and ITRC, Lucknow Regional Research Laboratory, Jammu ICVD, Chennai B.V. Patel PERD Centre, Ahmedabad International Practice School Stations: Ohm Laboratories, New Jersey, USA Uniformed Services University of the Health Sciences (USUHS) , Bethesda, USA

6. Faculty Strength [19] Professor- 02 Associate Professor- 01 Assistant Professor- 02 Lecturer- 10 Assistant Lecturer- 02 Project Assistants- 02 Faculty drawn from various disciplines across the Institute for basic courses Research Fellows Fulltime (12) Part time (06) Faculty Development Programmes Options for doing Higher degree or Doctoral degree for junior teachers Intensive teaching workshops Subject workshops and hands-on training programmes Faculty/Students Exchange and Training Collaborations USUHS, Bethesda, Maryland, USA CDRI and ITRC, Lucknow B.V. Patel PERD Centre, Ahmedabad Kathmandu University, Kathmandu, Nepal Hetero Drugs, Hyderabad

7. Special Assistance Programme (SAP) Pharmacy group has got financial assistance under special assistance programme (SAP) of UGC at the level of Department Research Support (DRS) Financial assistance of Rs 32,60,000 for three years period National Awards Prof. M. L. Khorana Memorial Gold Medal for meritorious performance in B. Pharm. examination (1996, 1997, 1998, 1999, 2000, 2002) G. P. Nair IDMA award for meritorious performance in B. Pharm. examination (1996-2002,2004) Prof. B. M. Mithal memorial Gold medal for meritorious performance in B. Pharm. examination (2001, 2002, 2003) Shri CNVHB Gupta memorial Gold medal for meritorious performance in M. Pharm. examination (2001, 2002,2003)

8. Extramural Research Grants ( Received in last 5 years)

9. Extramural Research Grants ( Received in last 5 years) (Contd…)

10. Human Resource Development for other Organisations` Dr. Reddy’s Lab., Hyderabad; M.Sc.(Tech.) in Pharm. Chem., M.S. (Pharm. Opn. Mgt.) L V Prasad Eye Institute, Hyderabad; B.S., M.S. and M. Phil. in Optometry Shankara Nethralaya, Chennai; B.S. and M. Phil. in Optometry, M.S. Medical Lab. Tech. Institute of Cardio-Vascular Diseases, Chennai; B.S. and M. Phil. in Physician Assistant Pharmacy Dept., Kathmandu University; Instrumentals Methods of Analysis Hetero Drugs, Hyderabad Srides Arcolabs, Bangalore Shashi Phytochemical industries, Alwar; TQM, Validation and Documentation Science Exhibition Yearly all India exhibition and professional oriented gathering organized by the students of the Institute for the last 20 years (APOGEE) Poster/ paper presentation; Invited lectures Working/ non-working models and Theme related exhibits National Pharmacy Week Celebrations (Yearly) Exhibition, Lectures/ Seminars, Health awareness camps

11. Symposiums/ Workshops Organized International Symposium on “Emerging Trends in Proteomics and Genomics Education and Research” with Bio-Sciences Group (January 2003) 42nd IANCAS National Workshop on “Radio Chemistry & Applications of Radioisotopes” in collaboration with BARC, Mumbai & Bio-Sciences Group (December 2000) National seminar on “Direction of Pharmacy Education in the New Millennium” as part of the Golden Jubilee Celebrations of Group (November 2000) Indo-US Symposium & workshop on “Recombinant DNA Technology and its applications in Drug discoveries and Biotechnology” with Bio-Sciences Group. (February 1999) Late Prof. B. M. Mithal Memorial Lecture (Since 2001) Invited Lectures By eminent persons from Academic / Industry in the campus (at least 4 per semester) Invited lectures delivered by faculty in conferences/ other institutions- 9 Conference papers (Last 2 years) International- =15; National- =22 Journal papers (Last 2 years) International- >25; National- 10 Books published : - Textbooks- 05 , - Laboratory manual- 01

12. Laboratory and other facilities Central Analytical Laboratory Houses sophisticated analytical instruments- NMR, HPLC (2), GC, IR spectrophotometer, UV-visible Spectrophotometer (3), Spectrofluorimeter (2), Atomic absorption Spectrophotometer, High Voltage Electrophoresis, Gel Electrophoresis, Gel Drier, High Vacuum Lyophilizer, High efficiency ultra Centrifuges for gradient separation (2), and several other instruments Industrial Pharmacy Laboratory Facilities for pharmaceutical formulation manufacturing (tablets, capsules, ointments, liquid orals, parenterals) and in-process quality control procedures Formulation Development and Pharmacokinetics laboratory Facility for design and development of Novel and Controlled drug delivery systems Pharmacology and Physiology Laboratory Facility for screening and evaluation of NCE’s Synthetic Medicinal Chemistry Laboratory Facility for design, synthesis and process optimisation of potential anti-psychotic, anti-microbial, anti-cancer, anti-viral and anti-inflammatory agents

13. Radio-Isotope Laboratory Facility for gamma scintigraphy, gamma spectrophotometry, Beta counter study of reaction kinetics using radio labelled probes and estimation of radio probes by atomic absorption spectrophotometer Molecular Biotechnology Laboratory Facility for nucleic acid and protein isolation and purification, rDNA manipulations, Cloning experiments, DNA sequencing, PCR, Gel Electrophoresis and Gel Documentation System Community and Hospital Pharmacy Practice (Services provided by the department at Medical Centre, BITS and Birla Sarvajanik Hospital, Pilani) Patient counselling Rational drug prescription monitoring and Evidence Based Practice Adverse drug effect/ reaction monitoring and reporting Therapeutic drug monitoring Patient clinics/ health awareness camps for Diabetes, Hypertension, Asthma and TB Laboratory and other facilities (Contd..)

14. Other Facilities Computational Facility PARAM 10000 super computer- Drug design and Bio-informatics WinNonlin- Pharmacokinetic modelling Alchemy- Molecular modelling and design ChemDraw- Synthetic medicinal chemistry Library Facility Caters to fast changing developments and academics or research needs of various programmes in the field of pharmaceutical sciences Caters to several national and internationally published journals/ scientific publications in the area of pharmaceutical sciences (International – 09 and National- 05) Online e-Journal facility (J-portal and Science direct) Miscellaneous facilities Besides these, the Institute also has exceptional strength in the fields of microelectronics, digital systems, software development, flexible manufacturing systems, fiber optics, robotics, super-conductivity, solar energy, process control, power electronics etc. GOAL : “ TO PROVIDE QUALITY EDUCATION FOR ECONOMIC ADVANTAGE “

15. Focus of future research Design and development of new bioactive molecules : (anti-inflammatory, anti-hypertensive, anti-convulsant, anti-psychotic, anti-bacterial, anti-viral,anti-AIDS and 5-HT, Dopamine receptor modulators) Screening and evaluation of NCE’s, Receptor pharmacology and mechanism of action of drugs Development of pharmaceutical formulations and novel drug delivery systems Phamacokinetic studies Phytochemical investigations on selected natural products Pharmaceutical Analysis

16. Requirements Proposed Budget outlay (Amount in Lakhs) Creation of additional infra structural facility and modern sophisticated instruments / equipment for the development of the Pharmacy Group into “ A Centre of Excellence in Teaching, Research and Innovation in Pharmaceutical Sciences”, requires aforementioned funds. Efforts are going on to meet the target and inputs are welcome in this regard.

17. To create additional facilities for: Training of students as well as research needs at the first degree (B. Pharm.) as well as higher degree levels (M. Pharm. and Ph.D.) Modern industrial manufacturing equipments as per latest GMP and ICH guidelines for training of students (UG & PG) and fetching Industry sponsored projects in area of production process optimisation Providing extra thrust for research activities Development of pilot plant facility for optimisation of commercially viable synthetic process for NCE’s Development of Biotech. based pharmaceuticals and over coming their stability problems Computational facilities for computer aided drug design and related activities Training of manpower in industry and academia Justification for the Need

18. Drug Design and Synthetic Medicinal Chemistry QSAR studies on metaloprotinase Inhibitors Application of QSAR and QSPKR concepts in design of NCE’s with better biopharmaceutical profile Synthesis of pharmacological evaluation of novel 5-HT Modulators for cancer chemotherapy induced emesis Design and synthesis of novel semi-carbazone derivatives as potential anti-convulsants Design and synthesis of novel non-nucleoside reverse trascriptase inhibitors for the treatment of AIDS Design, synthesis and biological evaluation of Indan derivatives as possible anti-inflammatory agents Current Research Activities

19. Formulation Development and Phamacokinetics Studies on design of novel ocular drug delivery systems for NSAIDs and antibiotics Enhancement of bioavailability of various drugs through phamacokinetics and formulation approaches Studies on design and development of controlled release combined dose formulations of anti-tubercular drugs Studies on design and evaluation of gastro-retentive formulation of selected drugs Studies on design and development of buccal drug delivery system Design and development of nano-technology based formulation for anticancer drugs Current Research Activities

20. Molecular Pharmacology and Drug Analysis Pharmacological implications of brain renin-angiotensin system modulators for novel therapeutic implications Studies on interface phenomenon in drug action Studies on novel interventions in alcohol withdrawal symptoms Screening of NCE’s developed in in-house laboratory Analysis of drug in pure form, formulation matrices, biological matrices for invitro and invivo test samples using novel spectroscopic and chromatographic techniques Complete analytical profiling of new drug molecules – physicochemical parameters, stability studies and drug excipient interaction studies Current Research Activities