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Reasons behind the production of defected tablets through various processes - Pubrica

With increasing number of patients and diseases, the need for medicines is growing more than ever. This has created pressure on the pharmaceutical industries to product high quality of medicines.<br>Continue Reading: https://bit.ly/3sHtJAZ<br>For our services: https://pubrica.com/services/research-services/<br>

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Reasons behind the production of defected tablets through various processes - Pubrica

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  1. REASONS BEHIND THE PRODUCTIONOFDEFECTED TABLETS THROUGH VARIOUSPROCESSES AnAcademicpresentationby Dr.NancyAgnes,Head,TechnicalOperations,Pubrica Group: www.pubrica.com Email:sales@pubrica.com

  2. Today'sDiscussion Outline Introduction Capping Lamination StickingandPicking Tablet Hardness Conclusion

  3. Introduction With increasing number of patients and diseases, the needformedicinesisgrowingmorethanever. This has created pressure on the pharmaceutical industriestoproducthighqualityofmedicines. Tablets are a form of medicine which is solid and is givenas oraldosage. Tabletsarethehighestsellingdosageformofmedicine. Contd...

  4. Tablets are produced by mixing excipients and active pharmaceuticalingredient (API). The powder mixture is then compressed and a tablet in a solidform isobtained. Agoodtabletisfreefromanysortofdefects (pharmaguideline,2017). Commonissuesfacedintheproductdevelopment processes of tablets are as weight variation, hardness, friability, picking, laminating, mottling, sticking, capping, chipping,anddoublepressorimpression(Jonathan Gaik,2018). Contd...

  5. Among these mentioned defects laminating/capping, hardness,andpicking/stickingarethethreemost commonly encountered issues faced in the production processof makingtablets. Generally,thesedefectsstemfromvariousissuesin productionprocesswithunitupstream,tabletpress, compression failure, and prevention of proper ejection of theproduct ifit istoo wetor toodry. Other issues include Poor quality of formation of too many fines in the raw milling materials, process, defects in formulation process. bad compressibility and flowofthe powder(Rajani etal., 2018).

  6. Capping Cappingphenomenaoccurswhenthereisfractureat thetop of thetablet. The top layer gets separated and detached from the solidtablet body. This issue generally arises when air is trapped in the tabletspowdermaterialduringthecompressionstage. Cappingcanalsostemfromtheissueoffailureof compressionoftheformulationbecauseof accumulationofpowderfines(JonathanGaik,2018). Contd...

  7. Figure:Cappingdefect

  8. Lamination Thetermlaminationisusedwhenasplitoccurs anywhereinthetabletotherthanthetoplayer. Usually,laminationdefectissimilartocapping andcausedbythe sameissues. Nevertheless, it is essential to diagnose the issueoflaminationinapropermanner. Often, lamination occurs due to over compressionofthe tablets. Contd...

  9. Asgreatercompressioncancausethe granules to flatten out and thus prevent them frombinding together. Lamination may also occur when fine or light particlesdonotcombine,astheparticlesfail tocompresswell(JonathanGaik,2018). Contd... Contd...

  10. Sticking andPicking The defect of sticking happens when the formulation granulessticktothefaceof thepresspunch. Quitedifferently,pickingdefectoccurswhenthe mixture granules stick on the design embossing of the punchtipsuch asin logosorlettering. Both picking and sticking result in the production of defectivetablets. Inqualitycontrolofthetablets,generallyavisual inspectioniscarriedouttoidentifypickingandsticking. Contd...

  11. However,thismethodofvisualinspectionisvery time-consumingandtendstodecreasetheoverall productionyield ofthe tablet. Unfortunatelysometimesmanymanufacturershave no option but to carry out visual detection as a quality controlmeasure. When, the compression batch stage, of the product reach the the skilled operator should efficiently adjust the press to comply with the product’scharacteristic designs. Contd...

  12. The quality of the product is majorly affected by the tablet’spresssetup,operation,tooling,and maintenance. Theremaybecaseswhenthegranulesarenot completely dried, in other words they may be hard and dryontheoutside butwetandmoistinside. Thisscenariointurnseriouslyaffectsthetablet’s quality. Contd...

  13. Theundriedparticlescanbreakopenduring compressionandsticktothepunchpresssurfaces causingsticking. In such casesit is essential to keep checking the process of drying the granules (Rajani et al., 2018; Chattorajet al.,2018).

  14. TabletHardness Another issue arising in tablet production process isthevariationinthehardnessofthetablets. A soft tablet tends to cause a range of issues not onlyinthepressprocessbutalsointhe consistencyofthe product. Asofttabletcanleadtoproductrecalldueto poor film coating process and packaging of the product(Rajaniet al.,2018).

  15. Conclusion Tabletmanufactureisshownsignificantly increase the likelihood of tablet defects through breakageof tablets. Increasing tablet tensile strength provides some resistancetodefectsuponimpact. The remedies are change the solvent system, change the binder, reduce drying temperature anduseasmallerparticlesize,improperly mixeddyeespeciallyduringdirectcompression. Contd...

  16. Mix it properly and reduce size if it is of a larger sizetoprevent segregation. Tabletsarewidelyuseddosageformsbut defects in aesthetic appearance may lead to rejectionoftheiradministrationbypatient. Becarefulduringmanufacturingprocess. Contd...

  17. The cost vs benefit equation mainly focuses on the pharmaceutical innovationswhich will be an integralparttoaddressthischallenge. The adequacies of drug benefit programs and policiesthatfosterinvestmentinnewer medicines pay way for the new pharmaceutical environment.

  18. ContactUs UNITEDKINGDOM +44-7424810299 INDIA +91-9884350006 EMAIL sales@pubrica.com

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