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Light4LIFE Germany - the Center of Innovation in the Area of BioPhotonics

Learn about Light4LIFE, the leading center of innovation in bioPhotonics in Germany. Explore the field of optics and photonics, the use of light sources and detectors in medical research, and the partners involved in advancing this technology.

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Light4LIFE Germany - the Center of Innovation in the Area of BioPhotonics

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  1. Light4LIFEGermany - the Center of Innovation in the Area of BioPhotonics Michael Fedorov, MD, PhD Moscow, 05.12.2014

  2. Content • Optics & Photonics • BioPhotonics • Light4LIFE – Partners • OCT • Light4LIFE – Realization • Activities

  3. 1.Optics & Photonics • May 2000: German Agenda of the Federal Ministry of Education and Research (bmbf): »Optical Technologies for the 21st Century« • June 2001:Foundation of the 7 regional Competence Networks for Optical Technologies as a supporting measure of the bmb+f

  4. 1.Optics & Photonics The 9 regional Networks of Competence in OT

  5. 1.Optics & Photonics Production Volume in Germany Other states: 52% Baden-Wuerttemberg 25% Source: OPTECH CONSULTING - October 2007 Bavaria 23%  Almost 50% of the Production Volume in Optical Technologies of Germany is located in Baden-Wuerttemberg and Bavaria.

  6. 1.Optics & Photonics Bavaria: Production Volume in OT Production Volume in Bavaria [€] > 500 million 100 - 500 million < 100 million < 10% 10% – 19% 20% - 49% > 50%

  7. 1.Optics & Photonics Bavaria offers an excellent environment for OT: • more than 400 manufacturing companies • 9 universities and 17 universitiesof applied sciences • 8 research institutes in photonics • 40 service provider (software, consulting, etc.)

  8. 1.Optics & Photonics Thematic priorities: Photonics in Industrial Production Laser Materials Processing

  9. 1.Optics & Photonics Thematic priorities: Micro- and Nano-Technology

  10. 1.Optics & Photonics Thematic priorities: BioPhotonics, Medical and Life Science

  11. 2.BioPhotonics Thematic priorities: • Clinical biophotonics, whatisit? • Useof light sources and light detectors and photoactivedrugstoinvestigateormanipulatelivingnature BioPhotonics, Medical and Life Science

  12. 2.BioPhotonics Methods Diagnosis Therapy Endoscopy Endomicroscopy Fluorescence (w/o drugs) Optical coherencetomography (OCT) Confocal Two-photon excitation Diffuse opticalimaging Holography Raman Photoacoustics Biostimulation PhotodynamicTherapy (drug) Laser Surgery

  13. 2.BioPhotonics Clinical Biophotonics ‐ Fluorescence and other optical techniques to support intraoperative diagnostics Localization DOI Fl.tomography Fl.endoscopy Staging OCT Photoacoustics Grading ConfocalEndoscopy 2-Photon Endoscopy OCT Moleculartarget Fluorescenceendoscopy Function Lifetime Raman

  14. 1. Partners

  15. 1.1. Partner – Research • R&D for clinical applications in BioPhotonic • German-Russian Networking in clinical research. Scientific focuses: Photodynamic, Biotechnology and BioPhotonic. • Cooperates with research facilities and hospitals from Russia for a long time • Research activities in Germany and Russia  Many contacts with Russia

  16. 1.2. Partner – Industry German branch of the Thorlabs Inc. ~ 100 employees • Main areas of activity: • R&D, production of test & measurement equipment • Technical Sales & Support of all catalogue products • Logistic hub for other European Thorlabs entities • Spectral Domain-OCT technology: • 4 standard products released to market • Several projects in medical market segments

  17. 1.3. Partner – Network • Cluster for optical technologies • German wide networking via OptecNet Germany • Strong international networking • Experience in location marketing and public relations • Support the organization of events and exhibitions (e.g. Photonica Moscow and LASER - World of Photonics / Munich)

  18. 3.1. We realize… … a concrete win-win project with mutual learning in the area of clinical BioPhotonics Technology: Optical Coherence Tomography (OCT) Application: Medical Partners: Light4LIFE – Universities in RUS

  19. 3.2. Optical Coherence Tomography (OCT) 3D image OCT OCT - principle normal eyeground

  20. 3.2. Optical Coherence Tomography Intra-operative diagnostics • Aim is „optical biopsy“: • Localization • Staging • Grading Normal bladder Bladdercancer Ultrasound-like images Resolution: ca. 10 µm Depth: 1-2 mm

  21. 3.2.1. OCT Example OCT bladder normal Karl et al., J Endourol 2008 Nephrogenic adenoma

  22. 3.2.2. OCT Example normal pT2G3 inflammation CIS invasive SCC

  23. 3.2.2. OCT Example OCT cervix Clinical studywith 120 pts: Gallwas et al., Las SurgMed 2011

  24. 3.3. Partners in Russia • Moscow – Exhibition Photonica • Nizhny Novgorod – Center for BioPhotonics • Novosibirsk – Academy of medical sciences, Center for research in physics

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