1 / 9

Molecular Basis for Relationship between Genotype and Phenotype

Molecular Basis for Relationship between Genotype and Phenotype. genotype. DNA. DNA sequence. transcription. RNA. translation. amino acid sequence. protein. function. phenotype. organism. Point mutations at the molecular level. Base substitution: change in base of nucelotide pair

rlynch
Download Presentation

Molecular Basis for Relationship between Genotype and Phenotype

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation amino acid sequence protein function phenotype organism

  2. Point mutations at the molecular level Base substitution: change in base of nucelotide pair Base additions: insertion of nucleotide pairs Base deletions: deletion of nucleotide pairs

  3. Point mutations at the molecular level

  4. Consequences of Point Mutations within Genes

  5. Point Mutations Can Alter mRNA Splicing

  6. Point Mutations on Gene Products

  7. Mutation frequencies obtained with various mutagens in Neurospora Mutagens are agents that cause mutations. Anything that is capable of causing chemical changes in the structure of DNA (especially bases) is a mutagen. Mutagens differ in mutagenicity.

  8. The Ames Test Reveals Mutagenic Compounds Strain 1 - frameshift mutation Strain 2 - base substitution

  9. Ames Test Results1 Revertant colonies per culture plate. Treatment Control diethyl sulfate* ICR-191** TA1575 11 14,700 13 TA1578 25 0 450 TA1575 : his base substitution mutant TA1578 : his frameshift mutant * Highly toxic alkylating agent, occurs as colorless liquid with peppermint odor ** Acridine, colorless solid intercalating agent, known carcinogen 1 McCann etal., 1975. Proc. Natl. Acad. Sci. USA 72 979-983.

More Related