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Daily Temozolomide Following Failure of Prior RT + TMZ for GBM: Update on the RESCUE Study

Daily Temozolomide Following Failure of Prior RT + TMZ for GBM: Update on the RESCUE Study J. Perry, W. Mason, K. Belanger, P. Kavan, D. Fulton, J. Easaw, S. Kirby, D. MacDonald, C. Shields and J.-F. Pouliot.

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Daily Temozolomide Following Failure of Prior RT + TMZ for GBM: Update on the RESCUE Study

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  1. Daily Temozolomide Following Failure of Prior RT + TMZ for GBM: Update on the RESCUE Study J. Perry, W. Mason, K. Belanger, P. Kavan, D. Fulton, J. Easaw, S. Kirby, D. MacDonald, C. Shields and J.-F. Pouliot

  2. 42-year-old woman with GBM treated with daily temozolomide at first relapse on the NCIC-CTG/EORTC Trial CR after 4 cycles continuous TMZ 50 mg/m2 PD: 9 mo after RT/TMZ, 6 cycles adjuvant TMZ

  3. Temozolomide Dose-intense Rescue

  4. RESCUE Study Design

  5. Study Objectives

  6. Main Inclusion Criteria

  7. Main Exclusion Criteria

  8. Demographics

  9. Six-month Progression-free Survival

  10. Progression-free Survival (by subgroup)

  11. Non hematological Toxicity (worst grade) *All AEs irrespective of causality incidence >2% No Grade 4 toxicity reported at this point in time

  12. Hematological Toxicity(worsened grade since baseline)

  13. Baseline Hematological Abnormalities(all patients)

  14. Conclusions

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