1 / 4

Osteoscoop - Issue N°227 – March 2012

Osteoblast extracellular Ca2+ sensing receptor regulates bone development, mineralization, and turnover. Osteoscoop - Issue N°227 – March 2012. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. CaR. Preosteoblast. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. CaR. Preosteoblast. WT. CaR KO.

rowan-holden
Download Presentation

Osteoscoop - Issue N°227 – March 2012

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Osteoblast extracellular Ca2+ sensing receptor regulates bone development, mineralization, and turnover Osteoscoop - Issue N°227 – March 2012

  2. Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ CaR Preosteoblast

  3. Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ CaR Preosteoblast WT CaR KO • Lower trabecular bone volume • Higher cortical bone porosity • Lower BMD • Altered mineralization • Smaller and lighter mice • Frequent fractures • Die at 3-4 weeks old

  4. Ca2+ Ca2+ Ca2+ Alters osteoblast differentiation Affects bone mineralization Ca2+ OPG CaR Ca2+ CaR NPP1 RANKL ANK OPN Preosteoblast RANKL Favors bone resorption RANK Preosteoclast WT CaR KO • Smaller and lighter mice • Frequent fractures • Die at 3-4 weeks old • Lower trabecular bone volume • Higher cortical bone porosity • Lower BMD • Altered mineralization

More Related