1 / 6

ICS favors long-term outcome in childhood asthma

ICS favors long-term outcome in childhood asthma. Dr. Gautam Sadhukhan. INFLAMMATION. INDUCERS Maternal smoking, Chemicals, Air pollutants, Virus infections. Inhaled CORTICOSTEROIDS. Genetic propensity. Airway Hyperresponsiveness. Airflow Limitation. TRIGGERS Allergens, Exercise

saskia
Download Presentation

ICS favors long-term outcome in childhood asthma

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. ICS favors long-term outcome in childhood asthma Dr. Gautam Sadhukhan Dr. G.Ghosh & Dr. G.Sadhukhan

  2. INFLAMMATION INDUCERS Maternal smoking, Chemicals, Air pollutants, Virus infections Inhaled CORTICOSTEROIDS Genetic propensity Airway Hyperresponsiveness Airflow Limitation TRIGGERS Allergens, Exercise Cold Air, SO2 Particulates SYMPTOMS Dr. G.Ghosh & Dr. G.Sadhukhan

  3. Superimposed acute inflammation Chronic inflammation Airway remodeling Structural changes Time Inflammation in asthma ICS Dr. G.Ghosh & Dr. G.Sadhukhan

  4. PEP Talk Natural history of asthma 2 out of 3 children with asthma outgrow their symptoms Risk factors for asthma persisting into adulthood • Female • Eczema • Onset after age of 3 years • Severe disease • Parental history of atopy / asthma Dr. G.Ghosh & Dr. G.Sadhukhan

  5. Methacholine Challenge Test CAMP study; NEJM 2000 Methach. Requ. To Produce Fall In FEV1 ICS Placebo Airway Hyper responsiveness Time : 4 to 6 years Dr. G.Ghosh & Dr. G.Sadhukhan

  6. M’Lord & H’able Juries • ICS specifically inhibit inflammation so long it is used!(NHLBI & GINA Studies, 1997-2002) • Airway hyper-responsiveness.: Definite improvement (CAMP study; NEJM 2000) • All wheezers improve in both acute and chronic symptoms. (Martinez FD ; Pediatrics 2002). • Airway remodelling: may be preventable if ICS are used in right time and duration (Bisgaard. H. Am J Resp Care 1996) Dr. G.Ghosh & Dr. G.Sadhukhan

More Related