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The Syndromal Child

Definitions. MalformationDeformationDisruption. SequenceSyndromeAssociation. Malformation. a morphologic defect of an organ, part of an organ, or larger area of the body resulting from an intrinsically abnormal developmental process"e.g., cleft lip. Deformation. abnormal form or position of a

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The Syndromal Child

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    1. The Syndromal Child Michael Underbrink, MD Ronald Deskin, MD

    2. Definitions Malformation Deformation Disruption Sequence Syndrome Association

    3. Malformation “a morphologic defect of an organ, part of an organ, or larger area of the body resulting from an intrinsically abnormal developmental process” e.g., cleft lip

    4. Deformation “abnormal form or position of a body part caused by nondisruptive mechanical forces” Usually late in fetal development Mechanical, malformational or functional e.g., Potter

    5. Disruption “defect of an organ, part of an organ, or a larger area of the body due to interference with a normal process” Sporadic and rare e.g., anmiotic bands leading to amputations

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