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RESULTS 1. INTRODUCTION. METHODS. TABLE 2 - ADVERSE EVENTS ( According To Ellis Classification ). TABLE 1- BASIC CHARACTERISTICS. OBJECTIVES. RESULTS 2. TABLE 3 - POOLED BAYESIAN ANALYSIS. CONCLUSIONS.

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RESULTS 2

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  1. RESULTS 1 INTRODUCTION METHODS TABLE 2 - ADVERSE EVENTS ( According To Ellis Classification ) TABLE 1- BASIC CHARACTERISTICS OBJECTIVES RESULTS 2 TABLE 3 - POOLED BAYESIAN ANALYSIS CONCLUSIONS Coronary Artery Perforation during Percutaneous Coronary InterventionsAvi Shimony1,2, Salvatore Mottillo1,3, Mark J. Eisenberg1,2,4 1. Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, QC 2. Lady Davis Institute for Medical Research, Jewish General Hospital/ McGill University, Montreal, QC 3. Faculty of Medicine, University of Montreal, Montreal, QC 4. Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC Coronary artery perforation (CAP) is a rare but life threatening complication of percutaneous coronary intervention (PCI). Because of its rarity, observational studies investigating CAP have been underpowered to examine incidence, risk factors, outcomes and management. Patients with Ellis II CAP had higher rates of tamponade and MI compared to patients with Ellis I CAP; however mortality rates were similar. Patients with Ellis III CAP had the highest rate of adverse events, with a more than 10 fold increase in tamponade and death compared with patients with Ellis II CAP (Table 3). To pool the results of observational studies investigating CAP in order to determine the incidence of CAP and in-hospital adverse events. CAP definition - CAP was classified according to the Ellis classification scheme. I -Development of an extra-luminal creator without extravasation. II - Development of pericardial or myocardial blush without contrast jet extravasation. III - Development extravasation jet through frank (≥1 mm) perforation or cavity spilling into an anatomic cavity chamber (ventricles, pericardial space etc.). Search strategy - The PUBMED and EMBASE databases were searched (January 1990 - December 2009) to identify observational studies of CAP. We excluded case reports, non-human studies, non-English language studies, and studies where CAP was not reported according to the ACC/AHA classification scheme. Statistical analysis - Incidence estimates across studies were summarized using a two-level Bayesian hierarchical model. % ; 95% Crl (the Bayesian analog to standard confidence intervals) The reported incidence of CAP in the preceding 20 years ranges from 0.1% to 0.84%. In-hospital adverse events associated with CAP vary directly with Ellis classification. Treatment should be tailored to the severity of CAP and the patient’s clinical status. Ellis III We identified a total of 16 studies involving 197,061 PCIs, 780 of which were complicated by CAP (0.4% ; 95% C.I 0.37-0.43) (Table 1). In-hospital adverse events included tamponade, MI and death (Table 2).

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