100+ 2 naphthylamine PowerPoint (PPT) Presentations, 2 naphthylamine PPTs

2 naphthylamine - PowerPoint PPT Presentation

Induction

Induction. Increased transcription Increased protein synthesis Enhanced stability of protein Synthesis of enzyme with higher catalytic activity. Inducible forms of CYP: CYP1A1 (PAH), CYP2B, CYP3A4 (PB), CYP2E1 (EtOH) Constitutive: CYP2A http://medicine.iupui.edu/flockhart/table.htm.

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539 views • 35 slides

Phase II: Conjugation

Phase II: Conjugation. Synthetic reaction of a xenobiotic (or of a Phase I metabolite of a xenobiotic) with an endogenous substance Results in introduction of polar, ionizable groups to enhance water solubility and hence excretion. Major Phase II reactions. Glucuronidation Sulfation

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534 views • 33 slides

Induction

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328 views • 20 slides

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2 naphthylamine - PowerPoint PPT Presentation

Induction

Phase II: Conjugation

Induction