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CHMI 4237 E Special topics in Biochemistry

CHMI 4237 E Special topics in Biochemistry. Stress signaling. Eric R. Gauthier, Ph.D . Dept . Chemistry - Biochemistry Laurentian University. Hypoxia. Mechanical. Oxidative. Viruses. Chemicals. Nutrient. Radiation. Osmotic pressure. Cell stresses. Heat. ?. Cell cycle arrest.

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NQ-1 ???? AMPK ???????????????

NQ-1 ???? AMPK ???????????????.

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Fig.A: Ethanol Treatment vs Culture Medium

Fig.A: Ethanol Treatment vs Culture Medium. 1% Ethanol in culture medium. Culture medium. Fig.B: TXL/PA Treatment vs PA Treatment. p53. AMPK. TXL (100 ?g/ml) preconditioning + PA (0.3 mM) treatment. PA (0.3 mM) treatment.

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Supplemental Figure 6

*. *. A. B. phospho-AMPK. **. 4. AMPK. 3. vehicle. g-Adipo. Phospho / total (fold). phospho-mTOR. 2. 1. mTOR. 0. AMPK. phospho-p70 S6K. 1.2. 1.0. P70 S6K. 0.8. Phospho / total (fold). 0.6. **. 0.4. phospho-S6 protein. 0.2. 0. S6 protein. mTOR. p70 S6K. S6 protein.

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pNIC

pNIC. NIC FF. NIC LKB1 KD. -. +. +. +. -. +. +. +. -. +. +. +. Serum. Hrs: Metformin ( 5mM). -. -. 1. 6. -. -. 1. 6. -. -. 1. 6. LKB1. 50. 75. pAMPK (T172). 50. 75. AMPK. 50. pACC. 250. ? -Tubulin. 50. Dupuy et al ., Additional file 1: Figure S1.

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CHMI 4237 E Special topics in Biochemistry

NQ-1 ???? AMPK ???????????????

Fig.A: Ethanol Treatment vs Culture Medium

Supplemental Figure 6

pNIC