'Cytochrome p450' presentation slideshows

Nutraceutical-Drug Interaction and CYP450 Pharmacology

Nutraceutical-Drug Interaction and CYP450 Pharmacology. Rodney McKeever,MD UCLA K-30 Program. INTRODUCTION. Plants used as medicines for thousands of yrs Used by all major cultures Saw palmetto used in Egypt in the 15 th century BC

1.26k views • 77 slides

1.29k views • 67 slides

Same Medicine, Different Result Pharmacogenetics: Where Are We Now?

980 views • 65 slides

Biotransformation of Xenobiotics

Biotransformation of Xenobiotics. Overview. Phase I and Phase II enzymes Reaction mechanisms, substrates Enzyme inhibitors and inducers Genetic polymorphism Detoxification Metabolic activation. Introduction. Purpose Converts lipophilic to hydrophilic compounds Facilitates excretion

1.04k views • 64 slides

Antiplatelet Therapy in General Overview

948 views • 56 slides

Biotransformation of Xenobiotics

Biotransformation of Xenobiotics. Overview. Phase I and Phase II enzymes Reaction mechanisms, substrates Enzyme inhibitors and inducers Genetic polymorphism Detoxification Metabolic activation. Introduction. Purpose Converts lipophilic to hydrophilic compounds Facilitates excretion

848 views • 55 slides

Alkylating Agents

Alkylating Agents. Dr Hayder B Sahib. Mechlorethamine Mechlorethamine was developed as a vesicant (nitrogen mustard) during World War I .

595 views • 42 slides

Hepatic Physiology

1.27k views • 41 slides

Cytochrome P450

Cytochrome P450. Lecture 8 Modified from textbooks, journals and internet sources. Introduction. Cytochrome P450 (P450) ? very large and diverse superfamily of hemoproteins range of proteins found in all domains of life

1.34k views • 34 slides

Metabolism of porphyrins: metabolism of bile pigments, biochemistry of jaundices .

Metabolism of porphyrins: metabolism of bile pigments, biochemistry of jaundices. JAUNDICES. NORMAL METABOLISM OF BILE PIGMENTS. albumin. CELLS OF RES. Indirect bilirubin 1,7-20,5 mkmol/l. Indirect bilirubin. Indirect bilirubin. UDP-glucoronil-transferase. NADP +.

825 views • 30 slides

Drug Metabolism

Drug Metabolism. Where? First-Pass Effect More than 1 metabolite! Varies depending on species, age, gender, genetic variation, disease. Phase I Oxidations Reductions Hydrolysis. Phase II Synthetic/Conjugation. Phases of Drug Metabolism. Phase I Oxidations.

542 views • 27 slides

Phytoremediation and P hytosensing of Explosives: The T arget genes

Phytoremediation and P hytosensing of Explosives: The T arget genes. By: Ariel Moore. Background. Plant metabolism of xenobiotics has three phases Activation (transformation) Conjugation Compartmentation (elimination) . Need to Know. TNT 2, 4, 6-trinitortoluene RDX

413 views • 23 slides

383 views • 23 slides

C P F M Chemical Proteomics Facility at Marquette

Internet2: Enabling Post-Genomic Technology at Marquette. C P F M Chemical Proteomics Facility at Marquette. The post-genomic challenge Exploring function across protein families using chemical probes. Basic research. Applied research.

265 views • 16 slides

Toxaphene

371 views • 12 slides

DETOXIFICATION OF TOXIC SUBSTANCES IN LIVER

Biotransformation of xenobiotics and endogenous toxins in the liver: microsomal oxidation , cytochrome ? -450. DETOXIFICATION OF TOXIC SUBSTANCES IN LIVER. Phase I and phase II . Phase I : hydrolysis, reduction, oxidation .

324 views • 12 slides

262 views • 11 slides

Design of soluble epoxide hydrolase inhibitors as drug leads

Design of soluble epoxide hydrolase inhibitors as drug leads. Junghwa Kim, Elise Pellmann, Mike Wild Daniel Sem, Ph.D. John Imig, Ph.D. sEH: biology. Epoxyeicosatrienoic acids (EETs) Cytochrome P450 Vasodilation, anti-inflammatory, angiogenesis. sEH inhibition. sEH: biochemistry.

276 views • 8 slides

?????????? cytochrome P450 ????????????

?????????? cytochrome P450 ????????????.

164 views • 2 slides

John T. Groves Princeton University NSF9810248 Norcarane Reveals A Radical Mechanism for Cyt P450

John T. Groves Princeton University NSF9810248 Norcarane Reveals A Radical Mechanism for Cyt P450.

115 views • 1 slides