'Dna glycosylase' presentation slideshows

DNA replication and repair - Lecture 3

571 views • 35 slides

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

478 views • 34 slides

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

427 views • 34 slides

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

346 views • 34 slides

from Marnett and Plastaras, Trends Genet . 17 , 214 (2001)

Endogenous DNA Damage. from Marnett and Plastaras, Trends Genet . 17 , 214 (2001). Biological Molecules are Labile. RNA is susceptible to hydrolysis. Reduction of ribose to deoxyribose gives DNA greater stability. N-glycosyl bond of DNA is more labile.

312 views • 31 slides

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

516 views • 30 slides

from Marnett and Plastaras, Trends Genet . 17 , 214 (2001)

Endogenous DNA Damage. from Marnett and Plastaras, Trends Genet . 17 , 214 (2001). Biological Molecules are Labile. RNA is susceptible to hydrolysis. Reduction of ribose to deoxyribose gives DNA greater stability. N-glycosyl bond of DNA is more labile.

421 views • 30 slides

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

400 views • 30 slides

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

323 views • 30 slides

Figure 18.01 Tumors in human liver.

Figure 18.01 Tumors in human liver. Figure 18.02 Action of proto-oncogenes and tumor suppressor genes. Figure 18.03a Contact inhibition. Figure 18.03b Contact inhibition. Page 561a. Page 561b. Figure 18.04 the mismatch repair protein MutS bound to DNA. Figure 18.05 Base-excision repair.

350 views • 25 slides

Principle of Single Antigen Specificity

Principle of Single Antigen Specificity. Each B cell contains two copies of the Ig locus (Maternal and Paternal copies) Only one is allowed to successfully rearrange - Allelic Exclusion

691 views • 22 slides

Depurination

Depurination. Release of adenine or guanine bases. Deamination. Often converts cytosine to uracil. Pyrimidine Dimers. Linkage of adjacent pyrimidine bases. Summary Of DNA Damage. hydrolysis (including depurinations and deaminations) oxidation methylation.

1.79k views • 10 slides