'Extrinsic pathway' presentation slideshows

Drugs influencing coagulation

Drugs influencing coagulation . Dr Sanjeewani Fonseka Department of Pharmacology. Classes of Drugs. Prevent coagulation Dissolve clots Prevent bleeding and hemorrhage - Hemostatic Overcome clotting deficiencies (replacement therapies). Classes of Drugs. Prevent coagulation

1.47k views • 110 slides

Biopharmaceutical 12. Recombinant blood products and therapeutic enzymes

Biopharmaceutical 12. Recombinant blood products and therapeutic enzymes. Dr. Tarek El-Bashiti Assoc. Prof. of Biotechnology. Introduction Blood and blood products constitute a major group of traditional biologics.

2.47k views • 96 slides

Bleeding & Clotting Disorders I

Bleeding & Clotting Disorders I. Richard E. Freeman MD 2013. Overview. The Players Factor Deficiencies causing bleeding Dissolving the Clot The Clinical Presentation Other Causes of Bleeding Hypercoagulability. Bleeding Bleeding Diathesis. Clotting Hemostasis Coagulation

1.77k views • 90 slides

Coagulation Cascade of the Newborn

509 views • 38 slides

ASPIRIN ? Cox inhibition ? (PROSTACYCLIN) PGI 2 & TXA 2 (THROMBOXANE) LOW DOSE ASPIRIN

ASPIRIN ? Cox inhibition ? (PROSTACYCLIN) PGI 2 & TXA 2 (THROMBOXANE) LOW DOSE ASPIRIN. 1)PREVENT ARTERIAL THROMBOSIS IHD, STROKE 2) UNSTABLE ANGINA 3) RECENT MI 4) TIA 5) ARIFICIAL VALVES. 6) PTCA 7) PERIPHERAL ARTERIAL OCCLUSIVE DISEASE 8) CHRONIC LIMB ISCHEMIA. Aspirin ADR.

635 views • 34 slides

The Clotting Cascade and DIC

The Clotting Cascade and DIC. Karim Rafaat, MD. Coagulation. Coagulation is a host defense system that maintains the integrity of the high pressure closed circulatory system To prevent excessive blood loss after injury the hemostatic system Endothelial cells Platelets

500 views • 33 slides

Sequence of local events following device implantation

Sequence of local events following device implantation. Injury Injection, implantation, blood vessel damage Acute inflammation Polymorphonuclear leukocytes Chronic inflammation Monocytes and Macrophages Granulation tissue Fibroblasts and new blood capillaries Foreign body reaction

326 views • 30 slides

The Hematologic and Lymphatic Systems and Assessment

Adult Nursing. The Hematologic and Lymphatic Systems and Assessment. Blood and Blood Cells. Transport oxygen Remove wastes Blood components Plasma RBC WBC Platelets. Blood and Blood Cells. Formation of blood Liver Bone marrow Stem cells.

294 views • 27 slides

BLOOD

BLOOD. RBCs. Figure 12-68. The availability of dietary iron can be a limiting factor in erythropoiesis, so storage and recycling mechanisms are highly developed in humans, as protection from anemia. Figure 12-69. Erythropoiesis is hormonally regulated:

323 views • 22 slides

Chlamydiae

385 views • 19 slides

Updated Coagulation Cascade

Extrinsic Pathway. VII. Vascular injury. VIIa + TF. Fibrin polymers Insoluble fibrin. Fibrin polymers Soluble fibrin. Fibrinogen. Fibrin monomer. Updated Coagulation Cascade. Correction: Walsh PN. Biochemistry 2007,Nov 6; 46(44): 12886-12887. Intrinsic Pathway. surface HMWK PK.

1.43k views • 1 slides

XII

Blood Coagulation Cascade. Intrinsic Pathway. Extrinsic Pathway. XII. XIIa. VII. XI. XIa. IX. IXa. +. VIIa. TF. VIII. VIIIa. X. Xa. X. V. Va. Prothrombin. Thrombin. Fibrinogen. Fibrin monomer.

413 views • 1 slides

Extrinsic Apoptosis Pathway

As a surface receptor, for example, TNF receptor-1 (TNF-R1), it will interact with TNF to induce the recruitment of adaptor proteins such as Fas-associated protein with death domain (FADD) and Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD), which recruits a series of downstream factors, including Caspase-8, which is a critical mediator of the extrinsic pathway, resulting eventually in cell apoptosis.

78 views • 1 slides

Extrinsic Apoptosis Pathway

As a surface receptor, for example, TNF receptor-1 (TNF-R1), it will interact with TNF to induce the recruitment of adaptor proteins such as Fas-associated protein with death domain (FADD) and Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD), which recruits a series of downstream factors, including Caspase-8, which is a critical mediator of the extrinsic pathway, resulting eventually in cell apoptosis.

30 views • 1 slides