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? 65% ? -cell defect

Insulin Resistance. Normal ? -cells. Defective ? -cells. TYPE 2 DIABETES. Genetic Predisposition. Environmental Factors. Obesity. Hyperinsulinemia with Normal Glucose Tolerance. Impaired Glucose Tolerance. ? 65% ? -cell defect. Figure A1. Minimal Model. Glucose levels.

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? 65% ? -cell defect