'Gene rearrangements' presentation slideshows

Chapter 5 Organization and Expression of Ig Genes

Chapter 5 Organization and Expression of Ig Genes. l chain. k chain (n= ~85). H chain (n= ~134). Unique features of Ig genes (1) Vertebrates can respond to a limitless array of foreign proteins. Every Ab molecule contains a unique a.a.sequence

1.23k views • 71 slides

Phases of the humoral immune response

( review ). Phases of the humoral immune response. ISOTYPE SWITCH. Organisation of the functional human heavy chain C region genes. C m. C d. C g 3. C g 1. C a 1. C g 2. C g 4. C e. C a 2. J regions. Antibody isotype switching.

1.45k views • 57 slides

The Human Genomes

593 views • 48 slides

Lecture 6 Antibody genes II

Lecture 6 Antibody genes II. Mechanism of class switching Regulation of class switching Somatic mutation T cell dependent antibody response Affinity maturation T independent antibody responses. Review session Saturday Jan 22 4:00-6:50PM YORK 2722. Next time: Mid term test.

1.05k views • 46 slides

Lecture 6 Antibody genes II

Lecture 6 Antibody genes II. Mechanism of class switching Regulation of class switching Somatic mutation T cell dependent antibody response Affinity maturation T independent antibody responses. Review session Saturday Jan 22 4:00-6:50PM YORK 2722. Next time: Mid term test.

864 views • 46 slides

Lecture 6 Antibody genes II

Lecture 6 Antibody genes II. Mechanism of class switching Regulation of class switching Somatic mutation T cell dependent antibody response Affinity maturation T independent antibody responses. Review session Saturday Jan 22 4:00-6:50PM YORK 2722. Next time: Mid term test.

471 views • 46 slides

Acquired alterations of IGH and TCR loci in lymphoproliferative disorders

617 views • 43 slides

Chapter 14

Chapter 14. Molecular Oncology. Objectives. Contrast tissue-specific and tumor-specific molecular targets. List molecular targets that are useful for diagnosis and the monitoring of solid tumors. Explain how microsatellite instability is detected.

433 views • 43 slides

Molecular Oncology

Molecular Oncology. Chapter 14. Many Mutations Lead to Cancer. Normal Cell. First Mutation. Second Mutation. Third Mutation. Malignant Cells. Fourth or Later Mutation. Cancer is Caused by Nonlethal Genetic Mutations Affecting Certain Genes.

585 views • 39 slides

Chapter 9 T-Cell Receptor

Chapter 9 T-Cell Receptor. Self-MHC Restriction of the TCR. Structure of TCR. Structural Similarity between TCR and mIgM. ? Resembling Fab?. Organization and Rearrangement of TCR Genes. Identifying and Cloning the TCR Genes (Hedrick and Davis, 1984)

591 views • 36 slides

Analysis and Characterization of Nucleic Acids and Proteins

Molecular Diagnostics. Analysis and Characterization of Nucleic Acids and Proteins. 1. PROBES. Single-stranded DNA or RNA molecules used to detect complementary sequences. carry radioactive or chemical markers to facilitate their detection.

789 views • 26 slides

Molecular Haemato-Oncology at Bristol Genetics Laboratory

Molecular Haemato-Oncology at Bristol Genetics Laboratory. Kayleigh Templeman. http://www.nbt.nhs.uk/gps/services__referral/b/bristol_genetics_laboratory. Condition. Test. http://www.nbt.nhs.uk/gps/services__referral/b/bristol_genetics_laboratory. Condition. Test.

373 views • 21 slides

Chapter 11

Chapter 11. Organization and Rearrangement of BCR and TCR Genes. Overview of B-cell development. Organization of Ig gene segments in the mouse. V-variable D-diversity J-joining C-constant L-leader. V gene. ??????. RNA ??.

227 views • 15 slides

Conclusions

Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukaemia by flow cytometry in a multi-centre setting; a report from the UK ALL Flow MRD group.

137 views • 1 slides