'Pharmacokinetic interactions' presentation slideshows

Managing Multiple Medications in Patients with PAH

Managing Multiple Medications in Patients with PAH. ADAANI FROST, MD Director, Pulmonary Hypertension Center Professor of Medicine Baylor College of Medicine Houston, Texas. Learning Objectives (CME, CE, CPE). At the completion of this educational activity, participants should be able to:

805 views • 60 slides

Transporters and Their Role in Drug Interactions

Advisory Committee for Pharmaceutical Science - Clinical Pharmacology Subcommittee meeting Topic 2: Transporter-based interactions Rockville, MD, October 18, 2006 Transporters and Their Role in Drug Interactions Shiew-Mei Huang, Ph.D. Deputy Director for Science

1.81k views • 47 slides

Adverse Reactions, Pharmacovigilance and Interactions

Adverse Reactions, Pharmacovigilance and Interactions. Adverse Reactions. Any substance introduced into the body can pose a risk at normal doses, and all are potentially toxic if given in overdose

938 views • 47 slides

Pages 645 to 724

Pages 645 to 724. Mechanisms of Drug Interaction. Pharmacokinetic Reduced rate and/or completeness of absorption Altered bioavailabilty Reduced plasma protein binding Altered tissue distribution Altered hepatic metabolism Altered renal excretion Haemodynamic interactions Pharmacodynamic

580 views • 46 slides

Question

Approaches to Mitigating the Bioactivation Potential of Compounds in Lead Optimization Deepak Dalvie Pharmacokinetics, Dynamics and Metabolism Department Pfizer San Diego. Question. Is covalent binding or GSH Adduct Formation a kill shot for a candidate??.

675 views • 36 slides

Understanding Pharmacokinetic Variability and Managing Drug-Drug Interactions

Understanding Pharmacokinetic Variability and Managing Drug-Drug Interactions. Courtney V. Fletcher, Pharm.D. Dean, College of Pharmacy and Professor, Department of Pharmacy Practice and Division of Infectious Diseases University of Nebraska Medical Center Omaha, Nebraska USA. Disclosure.

819 views • 28 slides

Clinically Significant Drug Interactions

1.83k views • 27 slides

Specific Aim

Delivery (GD 19 in mouse). Oral Gavage (PND 1). (PND 2). (PND 4). (PND 7). (PND 14). Tissue Dosimetry in the pups and the dams using gas chromatography Analysis of transport proteins (i.e., albumin, lipoproteins) in maternal blood.

74 views • 1 slides