'Superiority trial' presentation slideshows

Statistical & Design Considerations for Non-inferiority trials

Statistical & Design Considerations for Non-inferiority trials. Andrew Nunn MRC Clinical Trials Unit London. Outline. What is a non-inferiority trial? How do they differ from superiority trials? What do the regulators say? How large do the trials need to be?

691 views • 53 slides

Rick Chappell, Ph.D. Professor Department of Biostatistics and Medical Informatics

633 views • 47 slides

Rick Chappell Professor Department of Statistics and

659 views • 47 slides

Rick Chappell Professor Department of Statistics and

481 views • 47 slides

Rick Chappell, Ph.D. Professor Department of Statistics and

436 views • 43 slides

Challenges of Non-Inferiority Trial Designs

Challenges of Non-Inferiority Trial Designs. R. Sridhara, Ph.D. Terminology. Superiority = Drug T better than Placebo (P) or T better than Active Control (C) C may or may not have known efficacy Non-inferiority (NI) = T not much less effective than C

470 views • 19 slides