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Transcription coupled dna repair - PowerPoint PPT Presentation

DNA REPAIR

DNA REPAIR

BIOCHEMISTRY

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645 views • 49 slides
from Marnett and Plastaras, Trends Genet . 17 , 214 (2001)

from Marnett and Plastaras, Trends Genet . 17 , 214 (2001)

Endogenous DNA Damage. from Marnett and Plastaras, Trends Genet . 17 , 214 (2001). Biological Molecules are Labile. RNA is susceptible to hydrolysis. Reduction of ribose to deoxyribose gives DNA greater stability. N-glycosyl bond of DNA is more labile.

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312 views • 31 slides
Oxidative Damage of DNA

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

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516 views • 30 slides
Oxidative Damage of DNA

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

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400 views • 30 slides
Oxidative Damage of DNA

Oxidative Damage of DNA

Oxidative Damage of DNA. Oxidative damage results from aerobic metabolism, environmental toxins, activated macrophages, and signaling molecules (NO). Compartmentation limits oxidative DNA damage. Oxidation of Guanine Forms 8-Oxoguanine. The most common mutagenic base lesion is 8-oxoguanine.

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323 views • 30 slides
The Mutability and Repair of DNA

The Mutability and Repair of DNA

The Mutability and Repair of DNA. REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of MutS and DNA

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553 views • 27 slides

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