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Overview Of Geant4 Medical Activities At Hampton UniversityJefferson Lab

Overview Of Geant4 Medical Activities At Hampton UniversityJefferson Lab. Hampton University - Hampton, VA http://www.jlab.org/~gueye/CAMI/cami_web Jefferson Lab - Newport News, VA http://www.jlab.org/glab. Source Uniformity 3D In-vivo Measurements Energy Dependence TeraWatt Lasers

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Overview Of Geant4 Medical Activities At Hampton UniversityJefferson Lab

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  1. Overview Of Geant4 Medical Activities AtHampton UniversityJefferson Lab Hampton University - Hampton, VA http://www.jlab.org/~gueye/CAMI/cami_web Jefferson Lab - Newport News, VA http://www.jlab.org/glab • Source Uniformity • 3D In-vivo Measurements • Energy Dependence • TeraWatt Lasers • Electromagnetic Physics • Other Research (p-therapy …) G4NAMU - SLAC 2006

  2. Beta Detector(Coll: NIST, Varian) → Uniformity/non-uniformity of sources → Absolute calibration of Brachytherapy sources → Removed transfer: films ↔ ionization chambers → Accuracy better than 100 μm (possibly: 50 μm) PhD Thesis: Lawrence Tynes Sr/Y-90 Preliminary Before After Deconvolve Physics Processes Data: 03/07/06 G4NAMU - SLAC 2006

  3. z y • Air Bubbles: 20-80 m • Medical Physics Parameters • Dose Rate • Anisotropic Function • Radial Dose Function • Monte Carlo Codes • General Particle Source (GPS) • Gaussian/Fermi/… Distributions • Density (water/air - 200 m layer) GESiB (Coll: MGH, Laval, McGill, Varian) Uniformity/non uniformity Of Brachytherapy Sources P-32: Φ=0.21 mm x L=20 mm Cylinders: number=100,wall =0.2 mm AAPM: TG43/60, Dose rate @ surface & 2 mm IAEA: %deviation from average (Req: <20%) PhD Thesis: Nnenna Onumah • Results for 80 m • 5% effect on all parameters • GPS/G (dE/dx): up to a factor of 2 modifications in all parameters • Patient density (dE/dx): • 10% (up to ~0.5 mm) - preliminary G4NAMU - SLAC 2006

  4. XY Dependence Z Dependence In-vivo DoseMeasurements (Coll: DePaul Hospital, Varian) XYZ Dependence → Real Time Measurements → Position, dose distribution → Treatment Plans: Verification, Adjustments PhD Thesis: Carlos Velasco Data: 03/07/06 G4NAMU - SLAC 2006

  5. Active Mammosite(Coll: Proxima Therapeutics, dePaul Hospital) → Real time measurements → Absolute position (≤ ±1 mm) → Absolute dose distribution BSc (MSU): Jacquelyn Winston BSc (HU): Thomas Cudjoe Data: 03/07/06 HDR Source G4NAMU - SLAC 2006

  6. → Energy dependence of cancer cells Master Thesis: Ariano Munden (qualitative) PhD Thesis: Rachel Black (high energy) PhD Thesis: Yuriy Prilepskiy (low energy) Mono EnergeticBrachytherapy Sources(Coll: Jefferson Lab, EVMS, ODU) Breast cancer cells Dipole 0.3-1 MeV Collimator & source (Sr-90) 1-2 MeV New Data Sets: 03/07/06 AIP (2006 APS): Newsletter/Nature/Science G4NAMU - SLAC 2006

  7. Advanced Laser Light SourceUltrafast & Interface Biology/Medecine 10 Hz, 300 mJ, 25 fs • Varennes, Canada • Dynamic of biological processes • Radiation safety (monitoring program) • Charged beams characterization • Medical Applications 100 Hz, 100 mJ, 25 fs G4NAMU - SLAC 2006

  8. Electromagnetic Physics In Geant4 208Pb(e,e’) - E = 100 MeV ~40% effect! • Experimental cross sections • JLab, NIST: 20 eV to 60 MeV • Unpolarized & Polarized Data • JLab Mott polarimeter runs Period: 1996-2006 Kinematics: 100 keV & 5 MeV – 173o Targets: Au, Cu, Al • New scattering chamber Fall 2006, angular distribution New detectors PhD Thesis: Michael Epps • Theoretical understanding • Coulomb corrections • University of Basel & INFN • Results by Summer 2006 G4NAMU - SLAC 2006

  9. Other Research p Proton therapy New HU Center • Construction: summer 2006 • First beam: ~2009 • Collaboration with MGH, Saclay & Orsay • Shielding calculation with Geant4 Postdoc: Vahagn Nazaryan Polarized beams in cancer treatments Jefferson Lab electron beam DePaul Linac for electron and photon beams PhD Thesis: Nanda Karthik Kaon therapy PhD Thesis:Solomon Sahle Convolution product & Lyapunov stability (Switzerland/France/Italy/Armenia) • Nuclear Physics form factors (validation) • Implementation in medical physics BS: Leslie Upton K+ π+ Preliminary Same depth = 28.5 cm Medium = water G4NAMU - SLAC 2006

  10. ! Questions ! G4NAMU - SLAC 2006

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