1 / 17

Hans VAN REMOORTEL Turkish Thoracic Society Congress April 3-7, 2013 Belek - Antalya

The relationship between symptom experience and the level of daily physical activity in patients with COPD. Hans VAN REMOORTEL Turkish Thoracic Society Congress April 3-7, 2013 Belek - Antalya. www.proactivecopd.com.

serena
Download Presentation

Hans VAN REMOORTEL Turkish Thoracic Society Congress April 3-7, 2013 Belek - Antalya

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. The relationshipbetweensymptomexperience and the level of dailyphysicalactivityin patientswith COPD • Hans VAN REMOORTEL • TurkishThoracic Society Congress • April 3-7, 2013 • Belek - Antalya

  2. www.proactivecopd.com The PROactive project is funded by the Innovative Medicines Initiative Joint Undertaking (IMI JU) # 115011; and matching funds at each academic institution Academic partners Patient / Scientific organizations EFPIA members Small Medium Enterprise

  3. Rationale • Functional performance (Kocks PCRJ 2011) • = activitiespeopleactually do • Reduces risk hospitalizationduetoexacerbation(Garcia-AymerichThorax 2003) • Relatedtoquality of life(Arne IJCOPD 2011) • Predictor all-causemortality(Garcia-rioChest 2012) 1.0 Q4 Q3 0.8 Probability of survival 0.6 Q2 0.4 Q1 80 60 0 20 40 Time (months)

  4. Rationale • Measurement(Kocks PCRJ 2011)

  5. Rationale Field assessment: Activity monitors (accelerometry (+ other sensors)) Rabinovich et al.; European Respiratory Journal; 2013 Van Remoortel et al.; Plos One; 2012

  6. Rationale Patient report: Clinical COPD Questionnaire (CCQ) functional status domain Adapted from T. van der Molen, Department of General Practice, University Medical Center, Groningen, The Netherlands

  7. Rationale Objectivemeasurements CCQ functional status domain 6 5 4 25000 20000 3 15000 CCQ functional status domain Steps.day-1 2 10000 5000 1 IV III C I II 0 I III IV II Shrikrishna ERJ 2012 Liu SWJ 2012 GOLD stage GOLD stage

  8. Rationale Objectivemeasurements CCQ functional status domain 1.0 1.0 Q4 <1 Q3 1 & <2 0.8 0.8 2 & <3 Probability of survival Probability of survival Q2 0.6 0.6 3 0.4 0.4 Q1 80 60 0 60 20 40 0 20 40 Time (months) Time (months) Garcia-rio, Chest, 2012 Sundh, IJCOPD, 2012

  9. Methods • Aim= Identifythe relationbetweenfunctional performance measuredby PRO and physicalactivity monitoring at the individualpatientlevel • Inclusion • + 40y • FEV1/FVC < 70% • +10 pack years • Exclusion • Impairment of normalmovementpatternunrelatedtorespiratorydisease • Otherrespiratorydisease

  10. Methods • Design Spirometry 6MWD mMRC CAT CCQ CRQ-SAS mMRC CAT CCQ CRQ-SAS mMRC CAT CCQ CRQ-SAS mMRC CAT CCQ CRQ-SAS V4 V1 V2 V3 14 days 14 days 14 days PA monitoring PA monitoring

  11. Results • Baseline characteristics

  12. Results • Physicalactivity monitoring • PatientReportedOutcome

  13. Results • Univariatecorrelations STEPS (amount) r= -0.51 r= -0.33 r= -0.50 r= -0.45

  14. Results • Univariatecorrelations INTENSITY DURING WALKING r= -0.49 r= -0.31 r= -0.49 r= -0.45

  15. Conclusion • Functional performance measuredwith a PRO is modestlyrelated to the amount and intensity of PA. • Information obtainedwith a PRO does not provide aninsight in the physicalactivity level of patientswith COPD and canthereforenotbeused as a surrogateforobjective PA measurement. • PROactive tool = capturingphysicalactivitybyanobjectiveassessment (activitymonitoring) ANDsymptomexperience of the patients (PRO).

  16. Prof. Dr. M. Decramer Prof. Dr. W. Janssens Prof. Dr. T. Troosters Prof. Dr. R. Gosselink

  17. Thankyouforyourattention! hans.vanremoortel@faber.kuleuven.be

More Related