Regitz-Zagrosek Nature Reviews Drug Discovery advance online publication;

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Regitz-Zagrosek Nature Reviews Drug Discovery advance online publication; published online 21 April 2006 | doi:10.1038/nrd2032.

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Regitz-Zagrosek Nature Reviews Drug Discovery advance online publication;

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Regitz-Zagrosek Nature Reviews Drug Discovery advance online publication; published online 21 April 2006 | doi:10.1038/nrd2032

Drug Design / drug discovery

Drug Design / drug discovery. Jerome Baudry Assistant Professor BCMB UT/ORNL Center for Molecular Biophysics. 2 previous incarnations: Research faculty at UIUC Research scientist at Transtech Pharma, Inc. . Drug Design / drug discovery. What’s a drug?

926 views • 26 slides

Drug Discovery

Drug Discovery. The use of solid phase combinatorial chemistry and parallel synthesis. Problems with Traditional Synthesis. 1 chemist 1 molecule Can only make one molecule at a time Each synthesis very time consuming Multistep syntheses have loss at each step

865 views • 34 slides

DRUG DISCOVERY

DRUG DISCOVERY. Random Search e.g., buying paintbrush, mop, hammer, gluestick, nail, etc. etc. for hanging a picture frame on the wall Rational Design e.g., buying a nail for hanging the frame Combinatorial Search

284 views • 10 slides

Nature Reviews/2012

Nature Reviews/2012. Next-Generation Sequencing (NGS): D ata Generation. NGS will generate more broadly applicable data for various novel functional assays P rotein-DNA binding Histone modification Transcript levels Spatial interactions Combination of applications into larger studies

209 views • 12 slides

Publication and Discovery XDS

Publication and Discovery XDS. IHE IT Infrastructure Webinar Series. What is XDS ?. The Cross-Enterprise Document Sharing (XDS) IHE Integration Profile facilitates the registration, distribution and access across health enterprises of patient electronic health records.

267 views • 14 slides

These findings are reported in Nature Materials as an Advance Online Publication:

Bismuth Qubits in Silicon Gregory S. Boebinger , Florida State University, DMR 0654118 Electron Magnetic Resonance (EMR) User Program.

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Vera Regitz-Zagrosek Cardiovascular disease in women & Gender in medicine

Gender Aspects in the Metabolic syndrome. Vera Regitz-Zagrosek Cardiovascular disease in women & Gender in medicine Charite and German Heart Institute, Berlin. Issues today:. Definition and diagnosis of the MetS Gender differences in incidence and prevalence

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Kessel and Hall Nature Reviews Drug Discovery 5 , 985 – 986 (December 2006) | doi:10.1038/nrd2023

Kessel and Hall Nature Reviews Drug Discovery 5 , 985 – 986 (December 2006) | doi:10.1038/nrd2023.

120 views • 1 slides

Jubb et al. Nature Reviews Cancer advance online publication;

Jubb et al. Nature Reviews Cancer advance online publication; published online 13 July 2006 | doi:10.1038/nrc1946.

221 views • 1 slides

Drug Design / drug discovery

646 views • 26 slides

Kaye and Krum Nature Reviews Drug Discovery 6 , 127 – 139 (February 2007) | doi:10.1038/nrd2219

Kaye and Krum Nature Reviews Drug Discovery 6 , 127 – 139 (February 2007) | doi:10.1038/nrd2219.

190 views • 1 slides

Pui and Jeha Nature Reviews Drug Discovery 6 , 149 – 165 (February 2007) | doi:10.1038/nrd2240

Pui and Jeha Nature Reviews Drug Discovery 6 , 149 – 165 (February 2007) | doi:10.1038/nrd2240.

230 views • 1 slides

Hajduk and Greer Nature Reviews Drug Discovery 6 , 211 –219 (March 2007) | doi:10.1038/nrd2220

Hajduk and Greer Nature Reviews Drug Discovery 6 , 211 –219 (March 2007) | doi:10.1038/nrd2220.

161 views • 1 slides

Nature Reviews Genetics

Nature Reviews Genetics. Yeast eukaryote model organism. Eukaryote ; mitochondria, organelles, cell cycle, etc. Eukaryote Plus ; haploid, diploid, extra-chromosomal DNA. Saccharomyces cerevisiae Baker’s Yeast. Yeast Genome Project. Yeast Genome Project finished in 1996,

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SM Paul, et al., Nature Reviews, Drug Discovery 2010

Major challenges Cost-constraints in health care Looming patent expirations Complex regulatory environment Falling R&D productivity. SM Paul, et al., Nature Reviews, Drug Discovery 2010. Major challenges Cost-constraints in health care Looming patent expirations

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Mazmanian and Kasper Nature Reviews Immunology advance online publication;

Mazmanian and Kasper Nature Reviews Immunology advance online publication; published online 06 October 2006 | doi:10.1038/nri1956.

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Browning Nature Reviews Drug Discovery 5 , 564 – 576 (July 2006) | doi:10.1038/nrd2085

Browning Nature Reviews Drug Discovery 5 , 564 – 576 (July 2006) | doi:10.1038/nrd2085.

98 views • 1 slides

Drug Discovery Process

Drug Discovery Process. Massimiliano Beltramo, PhD. Drug Discovery Process. Aim of the two lessons : To give an overview of the drug discovery process. At the end of the lessons you will gain a general idea of the steps necessary to move a new drug from the bench to the bedside.

813 views • 15 slides

Jia Nature Reviews Drug Discovery 5 , 269 –270 (April 2006) | doi:10.1038/nrd2017

Jia Nature Reviews Drug Discovery 5 , 269 –270 (April 2006) | doi:10.1038/nrd2017.

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Campbell et al. Nature Reviews Microbiology advance online publication;

Campbell et al. Nature Reviews Microbiology advance online publication; published online 02 May 2006 | doi:10.1038/nrmicro1414.

214 views • 1 slides

Data and Publication Discovery

Data and Publication Discovery. Brian Matthews, Information Management Group, STFC Rutherford Appleton Laboratory CLADDIER workshop, Chilworth, Southampton, UK 15 th May 2007. Microsoft’s Science 2020 Report.

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Antifungal drug discovery.

Antifungal drug discovery. Jem Stach. Fungal Infections. Fungi have emerged as the fourth most common hospital bloodstream infections. Nearly 40% of which prove fatal - particularly significant in patients that are immunocompromised. Resistance to existing classes of drugs is on the increase

359 views • 32 slides

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Regitz-Zagrosek Nature Reviews Drug Discovery advance online publication;

Regitz-Zagrosek Nature Reviews Drug Discovery advance online publication;

Presentation Transcript

Drug Design / drug discovery

Drug Discovery

DRUG DISCOVERY

Nature Reviews/2012

Publication and Discovery XDS

These findings are reported in Nature Materials as an Advance Online Publication:

Vera Regitz-Zagrosek Cardiovascular disease in women &amp; Gender in medicine

Kessel and Hall Nature Reviews Drug Discovery 5 , 985 – 986 (December 2006) | doi:10.1038/nrd2023

Jubb et al. Nature Reviews Cancer advance online publication;

Drug Design / drug discovery

Kaye and Krum Nature Reviews Drug Discovery 6 , 127 – 139 (February 2007) | doi:10.1038/nrd2219

Pui and Jeha Nature Reviews Drug Discovery 6 , 149 – 165 (February 2007) | doi:10.1038/nrd2240

Hajduk and Greer Nature Reviews Drug Discovery 6 , 211 –219 (March 2007) | doi:10.1038/nrd2220

Nature Reviews Genetics

SM Paul, et al., Nature Reviews, Drug Discovery 2010

Mazmanian and Kasper Nature Reviews Immunology advance online publication;

Browning Nature Reviews Drug Discovery 5 , 564 – 576 (July 2006) | doi:10.1038/nrd2085

Drug Discovery Process

Jia Nature Reviews Drug Discovery 5 , 269 –270 (April 2006) | doi:10.1038/nrd2017

Campbell et al. Nature Reviews Microbiology advance online publication;

Data and Publication Discovery

Antifungal drug discovery.

Vera Regitz-Zagrosek Cardiovascular disease in women & Gender in medicine