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A Tale of 3 Cities, the Maastricht Masters & the Tryptophan Depletion story Professor Sean Hood

A Tale of 3 Cities, the Maastricht Masters & the Tryptophan Depletion story Professor Sean Hood Consultant Psychiatrist University of Western Australia Perth, Australia. Servier + Pfizer Support. City # 1: Bristol. Tryptophan Depletion in Social Anxiety Disorder. Dr Sean Hood

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A Tale of 3 Cities, the Maastricht Masters & the Tryptophan Depletion story Professor Sean Hood

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  1. A Tale of 3 Cities, the Maastricht Masters & the Tryptophan Depletion story Professor Sean Hood Consultant Psychiatrist University of Western Australia Perth, Australia

  2. Servier + Pfizer Support

  3. City # 1: Bristol

  4. Tryptophan Depletion in Social Anxiety Disorder. Dr Sean Hood Presented at The European Certificate in Anxiety and Mood Disorders, Santa Margherita Ligure, 2000

  5. Tryptophan Depletion: Serotonin & Anxiety Study Protocol Overview Patient fails to respond to standard open treatment (by CGI-I score): Routine outpatient care Exclusion Criteria met: Routine outpatient care Exclusion Criteria met: Routine outpatient care Screening Day Standard open treatment3/12+ SSRI Day 1 Day 2 Post-Study Follow-up Recruitment

  6. Tryptophan Depletion: Serotonin & Anxiety SAnD TD: Protocol #1: Autobiographical Script #2:VerbalTask #3:NeutralScript Amino acid drink Qu. +2 hr Qu. +4 hr (fasting) Time (hrs) 0 +1 +2 +3 +4 +5 +6 +7 TRP Levels TRP Levels TRP Levels TRP Levels

  7. Subjects:n=14 SSRI-remittedSAnD (CGI 1 or 2) • Challenge: Autobiog. Script, Verbal Task, N. task • Measures: SSAI,VAS,LSAS,SPIN CVS

  8. Subjects:n=14 SSRI-remittedSAnD (CGI 1 or 2) • Challenge: Autobiog. Script, Verbal Task, N. task • Measures: SSAI,VAS,LSAS,SPIN CVS • Results: ATD

  9. Subjects:n=14 SSRI-remittedSAnD (CGI 1 or 2) • Challenge: Autobiog. Script, Verbal Task, N. task • Measures: SSAI,VAS,LSAS,SPIN CVS • Results: ATD • Challenge •  ATD x Challenge •  Psychological •  Physiological

  10. City # 2: Maastricht

  11. 2004 Summer Conference of the British Association for Psychopharmacology. Harrogate, UK.

  12. Acute Tryptophan Depletion in 5 clinical anxiety disorders:PD, SAnD, PTSD, GAD & OCD Neurotalk June 27th, 2010 Singapore Professor Sean Hood Consultant Psychiatrist University of Western Australia Perth, Australia

  13. 5 Clinical Anxiety Disorders

  14. Acute Tryptophan Depletion:Serotonin & Anxiety • Acutely Depleting Serotonin  Sx • (SSRI-remitted Depression) • SSRI-remitted SAnD (Social Anxiety) • SSRI-remitted PD (Panic) • CBT-remitted PD (Panic) • SSRI-remitted PTSD • Acutely Depleting Serotonin  NO Sx • SSRI-remitted GAD (Generalised Anxiety) • SSRI-remitted OCD (Obsessive Compulsive)

  15. ATD in Anxiety Summary

  16. City # 3: Perth

  17. Serotonin – HPA

  18. Serotonin – HPA

  19. 5HT & Hypertension & Stress(N) Volunteer Studies completed

  20. 5HT & Hypertension & Stress(N) Volunteer Studies over Past 5 Years

  21. Serotonin – Cardiovascular

  22. 5HT & Hypertension & StressDavies, Hood et al. J Clin Psychopharm.

  23. P & H: Autonomic Dysfunction

  24. P & H: Autonomic Dysfunction

  25. Networking

  26. P & H: Autonomic Dysfunction

  27. From Rags to Riches in 10 years: How the Maastricht Masters made me fantastically successful. Professor Sean Hood Consultant Psychiatrist University of Western Australia Perth, Australia

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