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CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY

CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY. BY: Mary Harrell, Farah Fevrier, Kareen Carty, Daniel Omotola, and Trey Palmer. PROBLEM. With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?.

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CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY

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  1. CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY BY: Mary Harrell, Farah Fevrier, Kareen Carty, Daniel Omotola, and Trey Palmer

  2. PROBLEM • With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?

  3. Risk Factors For CVD Tobacco Use Hypertension High Levels of Cholesterol Physical inactivity Diabetes High Triglyceride Levels Obesity Psychological & Social Factors Heredity Aging Male Ethnicity Syndrome X PROBLEM

  4. Risk Factors For CVD Tobacco Use Heredity High Levels of Cholesterol Physical Inactivity Diabetes High Triglyceride Levels Obesity Psychological & Social Factors Hypertension Aging Male Ethnicity Syndrome X PROBLEM

  5. BACKGROUND INFORMATION • Facts about Cardiovascular Disease • Mortality of CVD is 1½ times that of cancer • Quality of life diminished for 25% of population • Strokes account for 1/6 of all CVD hospitalizations • Congestive heart failure is most frequent cause of hospital visits by people over 65 • Impact is far reaching

  6. POSSIBLE SOLUTIONS • Gene Transfer • Modification • Genetically defective contractile proteins • Myocardial cells • Cardiac protein profile to rebuild muscle • Enhance contractility • Replacement • Artherosclerosis prevention • Regrowth • Alternatives to invasive surgery • Repair damaged tissue and improve heart function after infarction

  7. BEST SOLUTION • Regrowth with the use of Stem Cells • Proven successful on mice • Testing on non-human primates to begin • Angiogenesis “opens up” blocked vessels • Effectiveness on cardiac muscle

  8. CONCLUSION • With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes? • Push for gene therapy with stem cells on humans

  9. REFERENCES • Core Concepts In Health, by Insel & Roth pgs. 10, 428-436, 446, 454, 483 • Primary site – CVD/gene therapy paper http://oak.cats.ohiou.edu/~ed170793/paper.htm • Common viriants of most human genes www.ornl.gov/hgmis/publicat/hgn/v10n1/13lander.html • Understanding DNA variations www.ornl.gov/hgmis/publicat/hgn/v10n1/06snps.html • Explaining the human genome project www.nhgri.nih.gov/Policy_and_public_affairs/Communications/Publications/Maps_to_medicine/about/html

  10. REFERENCES 6. Angiogenesis www.bioportfolio.com/news/leaddiscovery_10.htm 7. Stem cells www.genome.gov/page.cfm?pageID=10000345 8. Gene clues and CVD www.the-aps.org/press_room?release2-19-02.htm 9. Use of stem cellls on mice www.seniors.gov/articles/0401/heartattack

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