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Benefits of Accutane

Benefits of Accutane. Guy F. Webster MD, PhD Vice Chair, Department of Dermatology Jefferson Medical College. Accutane. Orals and Topicals. Orals. Topicals. Psychosocial Effects of Acne. Acne is a long-lasting chronic disease Increased anxiety Increased depression

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Benefits of Accutane

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  1. Benefits of Accutane Guy F. Webster MD, PhD Vice Chair, Department of Dermatology Jefferson Medical College

  2. Accutane Orals and Topicals Orals Topicals

  3. Psychosocial Effects of Acne • Acne is a long-lasting chronic disease • Increased anxiety • Increased depression • Increased self consciousness and other parameters

  4. Emotional Impairment Due to Acne • Dermatology out-patients had higher prevalence of psychiatric disorders (Hughes et al, 1983) • Patients with severe acne were more anxious (van der Meeren et al, 1985) • Patients with severe acne had higher states of anxiety and anger (Wu et al, 1988) PSY130 6/16/00

  5. Isotretinoin • Correcting the altered pattern of follicular keratinization • Suppress sebaceous gland activity • Decrease P.acnes (the only organism implicated in the causation of nodular acne) • Anti-inflammatory

  6. August 24, 1998 December 2, 1998

  7. November 97 November 97 Christmas 97 March 98

  8. Accutane Improves Anxiety • Isotretinoin treatment produced significant improvements across wide variety of psychological functions (Kellett and Gawkrodger,1999) • Treatment with isotretinoin reduced anxiety and depression scores (Rubinow and Peck, 1987) PSY 040, (303), 9/1/00

  9. Benefits of Isotretinoin in Acne • Lasting response in disfiguring disease • Short duration of treatment • Long-term improvement in self-esteem and function

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