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Experiment Five: Microstimulation

Experiment Five: Microstimulation. Since nerves use electricity to communicate, they can be manipulated with electricity as well. Luigi Galvni discovered in the 1700s that electricity applied to the nerves of frog legs caused the large muscles to twitch.

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Experiment Five: Microstimulation

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  1. Experiment Five: Microstimulation

  2. Since nerves use electricity to communicate, they can be manipulated with electricity as well Luigi Galvni discovered in the 1700s that electricity applied to the nerves of frog legs caused the large muscles to twitch

  3. Is “animal” electricity different than the electricity of lightening storms? Galvani hung frog legs off his back porch during thunderstorms and watched the legs twitch.

  4. Can electricity applied to brain modify body function? Hitzig and Fritsch (1870): applied electrical current to dog cerebral cortex showed that stimulating different parts of brain causes different types of movement

  5. Present Day Neuromodulation Applications Deep Brain Stimulation Retinal Prosthetic implanted chip Which can help the symptoms of Parkinson’s but sometimes causes increased complusive behavior like gambling

  6. Exercise 1: Cockroach Leg Microstimulation Set up

  7. Exercise 2: Response of motor neurons to amplitude and frequency High amplitude Low frequency Low amplitude High frequency

  8. High amplitude = More Neural Tissue Affected High frequency = Individual Neurons Firing More Spikes (up to a limit?)

  9. Exercise 3: Recording and spike patterns from ganglia

  10. Identify relationships between leg movements and ganglia spike patterns

  11. Exercise 3B: Stimulation of metathoracic ganglion/ Effect of spike patterns and amplitude on movement“Copy Paste” or “Read Write”

  12. Exercise 3B: Stimulation of metathoracic ganglion/ Effect of spike patterns and amplitude on movement

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