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Part I Introduction to SHAKEN

Part I Introduction to SHAKEN. Attach. Penetrate. Release. Move. What if you forgot a step?. Missing Penetrate step. Can the virus attach to the cell? OK - the location of the virus can be near the cell Can the attach step performed properly? OK

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Part I Introduction to SHAKEN

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  1. Part I Introduction to SHAKEN

  2. Attach Penetrate Release Move What if you forgot a step? Missing Penetrate step Can the virus attach to the cell? OK - the location of the virus can be near the cell Can the attach step performed properly? OK - Virus and the cell become attached each other Can the viral-nucleic-acid move to the cytoplasm of the cell? No! - The virus is still outside the cell! • After the viral invasion, is the plasma membrane broken? No! • - There was no step that can break the plasma membrane !

  3. What if you chose wrong objects? Release • Can the viral-nucleic-acid be released? No! • It is not confined in the enclosure (cell membrane) • Question: what role(s) does cell membrane play in Release? • The viral-nucleic-acid is enclosed in the cell membrane when the acid is released  unexpected answer! virus cell object The-enclosure has-part has-part viral-nucleic-acid membrane

  4. How Do You Know You Are Done Teaching SHAKEN? • No errors are reported when SHAKEN executes the steps (running the simulation) • You ask a few key questions and the answers are as you expected

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