1 / 19

Imaging in the Courtroom: Alchemy is Back in Vogue University of Denver Sturm College of Law 3

What is an Image?. the vivid representation of anatomy or physiologythe pictorial or graphic display of dataImages are sexy, can convey an enormous amount of information AND can be used in a courtroom.

teddy
Download Presentation

Imaging in the Courtroom: Alchemy is Back in Vogue University of Denver Sturm College of Law 3

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. Imaging in the Courtroom: Alchemy is Back in Vogue University of Denver Sturm College of Law 3/4/2011 Jonathan D. Brodie, Ph.D., M.D. Dept. of Psychiatry

    2. What is an Image? the vivid representation of anatomy or physiology the pictorial or graphic display of data Images are sexy, can convey an enormous amount of information AND can be used in a courtroom

    5. PET Imaging of Amyloid Deposits in Alzheimers Disease vs Normal Controls Figure 4. PIB standardized uptake value (SUV) images demonstrate a marked difference between PIB retention in Alzheimer's disease (AD) patients and healthy control (HC) subjects. PET images of a 67-year-old HC subject (left) and a 79-year-old AD patient (AD6; MMSE = 21; right). (top) SUV PIB images summed over 40 to 60 minutes; (bottom)18FDG rCMRglc images ( mol/min/100ml). The left column shows lack of PIB retention in the entire gray matter of the HC subject (top left) and normal 18FDG uptake (bottom left). Nonspecific PIB retention is seen in the white matter (top left). The right column shows high PIB retention in the frontal and temporoparietal cortices of the AD patient (top right) and a typical pattern of 18FDG hypometabolism present in the temporoparietal cortex (arrows; bottom right) along with preserved metabolic rate in the frontal cortex. PIB and 18FDG scans were obtained within 3 days of each other. Figure 4. PIB standardized uptake value (SUV) images demonstrate a marked difference between PIB retention in Alzheimer's disease (AD) patients and healthy control (HC) subjects. PET images of a 67-year-old HC subject (left) and a 79-year-old AD patient (AD6; MMSE = 21; right). (top) SUV PIB images summed over 40 to 60 minutes; (bottom)18FDG rCMRglc images ( mol/min/100ml). The left column shows lack of PIB retention in the entire gray matter of the HC subject (top left) and normal 18FDG uptake (bottom left). Nonspecific PIB retention is seen in the white matter (top left). The right column shows high PIB retention in the frontal and temporoparietal cortices of the AD patient (top right) and a typical pattern of 18FDG hypometabolism present in the temporoparietal cortex (arrows; bottom right) along with preserved metabolic rate in the frontal cortex. PIB and 18FDG scans were obtained within 3 days of each other.

    6. Principles of Neuroimaging (I) Objective is to detect some property of the brain (as measured by attenuation of x-rays, magnetic moments or dipoles, electrical signals, radioactive events) without invading it Recognize that each imaging technique has a characteristic sensitivity, precision, accuracy and fidelity with respect to a physical and/or physiological process and generally in an artificial environment divorced from the very circumstances and behaviors that engendered the test.

    7. Structural Imaging CAT X-Ray MRI

    9. Proton density, recovery (T1) and decay (T2 and T2*) times.

    10. Functional Imaging PET f MRI EEG

    11. f MRI Paradigms (VF & Pharm) This shows the FDG image of the brain at various stages of life This shows the FDG image of the brain at various stages of life

    12. fMRI Setup

    13. Activation Statistics

    15. K-Space an MRI literature name for Fourier space

    16. PET This shows the FDG image of the brain at various stages of life Note that metabolism changes with ageThis shows the FDG image of the brain at various stages of life Note that metabolism changes with age

    18. Principles of Neuroimaging (II) Applying a model to interpret the signal Interpreting the reconstructed data in an experimental context or design Statistical analysis and comparisons Experimental conclusions or clinical inferences

    19. PET Analysis by within subject Subtraction: Individual Variance and Mean Difference

    20. Even Identical twins are not the same

More Related