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ANRS Satellite HIV-2: a model of attenuated HIV infection

ANRS Satellite HIV-2: a model of attenuated HIV infection. G Chêne, S Matheron, F Brun-Vézinet ANRS team: L Pedroza, G Betouret, S Couffin-Cadiergues JF Delfraissy. HIV-2: a model of attenuated HIV infection. HIV-2 as compared to HIV-1: Less pathogenic Slower disease progression

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ANRS Satellite HIV-2: a model of attenuated HIV infection

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  1. ANRS SatelliteHIV-2: a model of attenuated HIV infection • G Chêne, S Matheron, F Brun-Vézinet • ANRS team: L Pedroza, G Betouret, S Couffin-Cadiergues • JF Delfraissy

  2. HIV-2: a model of attenuated HIV infection • HIV-2 as compared to HIV-1: • Less pathogenic • Slower disease progression • Sustained durability of CD4 T cell number • Detection of plasma virus at low levels in a limited number of patients • Is HIV-2 infection really comparable to the exceptional HIV-1 elite controllers status? • Undetectable plasma RNA <50c/ml for at least 10 y, normal CD4 cell count, null CD4 slope • Predominant host genetic factors driving the robust cell-mediated immunity • Is HIV-2 infection a model for « functional cure »?

  3. HIV-2: Questions • Does the long control of HIV-2 infection result from the virus and/or from host’s defenses? • Overview: G Gottlieb • Molecular characteristics: F Kirchoff • Vpx: M Benkirane • Immunological responses: S Rowland-Jone • In the clinics, how to manage HIV-2 infected patients? • In the laboratories of virology: D Descamps • In the clinical units: S Matheron • How to progress on the knowledge of HIV-2 infection through collaborative studies? • The new ANRS HIV-2 immuno-virological network: F Brun-Vézinet • ACHIEV2E, COHERE & EuroCoord: G Chêne • IeDEA & RESAPSI: S Eholié

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