Erk Signaling Pathway

1. Erk Signaling Pathway The extracellular-signal-regulated kinase (ERK) pathway is one of the major signaling cassettes of the mitogen activated protein kinase (MAPK) signaling pathway. The ERK cascade is activated by a variety of extracellular agents, including growth factors, hormones and also cellular stresses to induce cellular processes that include mainly proliferation and differentiation, but under some conditions also stress response and others. The main MAPK/ERK kinase kinase (MEKK) components are the Raf family members Raf-1, A-Raf and B-Raf that phosphorylate two serine residues on the MAPK/ERK kinase (MEK) components MEK1/2. ERK1/2 are responsible for stimulating the downstream effectors, many of which are transcription factors. One of the major transcription factors is cyclic AMP response element-binding protein (CREB). JNK Signaling Pathway is ready at Creative Diagnostics for your research. This ERK pathway contributes to the control of a large number of cellular processes: • Regulation of cell proliferation such as T cell activation • Synaptic plasticity such as long-term potentiation (LTP) in hippocampal neurons • Proliferation of endothelial cells during angiogenesis • Phosphorylation of the transcription factor p53 • Remodeling the ERK signaling pathway may contribute to the development of polycystic kidney disease • Activation of phospholipase A2 (PLA2) in mast cells. http://www.creative-diagnostics.com/Erk-Signaling-Pathway.htm