Omentin Signaling Pathway

1. Omentin Signaling Pathway An overview of omentin Adipose tissue not only stores energy but also secretes a variety of inflammatory mediators and cellular factors. It secretes tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), leptin, retinol-binding protein, resistin, adiponectin, visfatin, etc., affecting carbohydrates and lipid metabolism and playing an important role in pathophysiological processes such as insulin resistance, type 2 diabetes, atherosclerosis, inflammatory dysfunction. Omentin is a new adipocytokine recently discovered, mainly produced by the secretion of visceral adipose tissue. In recent years, studies have shown that omentin is widely involved in a variety of pathophysiological processes such as obesity, insulin resistance, inflammatory response, atherogenesis, and regulation of vascular endothelial function. It has the functions of enhancing insulin sensitivity, anti-atherosclerosis, reducing inflammation, regulating vascular endothelial cell function, cardiovascular protection, and is closely related to various clinical diseases such as diabetes, cardiovascular diseases, autoimmune diseases, and tumors. Therefore, it is particularly important to study the omentin signaling pathway. response, and vascular endothelial Omentin family Sequence analysis of the omentin protein revealed that it is 1269 bp in length and encodes a 313 amino acid peptide chain containing a secreted signal sequence and a fibrinogen-associated region. The latter is a 296 amino acid globular structure with a molecular weight of 33 kD, including: β -chain and γ -chain of fibrinogen; Peroxisome proliferating protein-activated receptor γ-encoded angiogenin-related protein (PGAR); Binds to wrist protein. Compared to SAT, omentin has a highly selective expression in VAT. Real-time PCR assays showed that omentin mRNA was expressed in retinal adipose stromal vascular cells, but not in adipocytes, and was 150-fold higher than SAT. The results of hybridization experiments with nucleic acid molecules showed that in addition to high expression in omental adipose tissue, omentin is highly expressed in human placenta and ovary, low in small intestine, lung and heart, and is only detectable in muscle and kidney. In other organs or tissues, it is not detected at all. https://www.creative-diagnostics.com/omentin-signaling-pathway.htm