P38 Signaling Pathway

1. P38 Signaling Pathway The p38 pathway is the third major signaling cassettes of the mitogen-activated protein kinase (MAPK) signaling pathway. It functions in the control of apoptosis and the release of cytokines by macrophages and neutrophils. The pathway takes its name from the family of p38 kinases, which are the MAPKs that interact with the final effectors. The p38 family members possess a TGY motif in the activation segment. Like JNK pathway, p38 signaling are strongly activated by environmental stresses and inflammatory cytokines. Its activation contributes to inflammation, apoptosis, cell differentiation, and cell cycle regulation. P38 kinase was found in 1993 by Brewster and his colleagues when they study the influence of hypertonic environment to fungus. Then, it was found to be exist in mammalian cells. P38 is also one of the subtype of MAPKs, similar to JNK, it is belong to stress activated protein kinase. Now there are 5 different P38 protein kinase identified, which are p38α, p38β1, p38β2, p38γ, p38δ. The distribution of these P38 kinase are different, p38α, p38β1, p38β2 are extensively existed in various of cells and tissues, while p38γ is only existed in skeletal muscle cell and p38 δ is mainly existed in glandular tissue. P38 Signaling Pathway is ready at Creative Diagnostics for your research. http://www.creative-diagnostics.com/P38-Signaling-Pathway.htm