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Antibacterial agent

Department of Chemical and Materials Engineering , National Yunlin University of Science and Technology, 123 University Road, Section 3, Douliou, Yunlin 64002, Taiwan, R.O.C. Antibacterial agent. Shen You-Sheng , 沈祐陞. 技術簡介.

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Antibacterial agent

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  1. Department of Chemical and Materials Engineering , National Yunlin University of Science and Technology, 123 University Road, Section 3, Douliou, Yunlin 64002, Taiwan, R.O.C. Antibacterial agent Shen You-Sheng , 沈祐陞 技術簡介 有鑒於目前的研究,4-pyrrol-1-yl benzoic acid hydrazide類似物以及一些衍生物如5-substituted-2-thiol-1,3,4-oxadiazoles,5-substituted-4-amino-1,2,4-triazolin-3-thione和2,5-dimethyl pyrroles已被合成出來做為抗菌劑,也有很不錯的產率,也已有對其特性去做IR、NMR、MS、EA等等的分析。初步估算這些化合物在體外對於格蘭氏陽性和格蘭氏陰性菌的抗菌活性,而這些化合物都展現了很好的抗菌性。所以本實驗中我們使用4-pyrrol-1-yl benzoate與hydrazine先合成出4-pyrrol-1-yl benzoic acid hydrazide再進一步對此化合物進行改良,進而合成其他的衍生物做為抗菌劑,目的是為了探討這種結構上的變異的抗菌活性。 搜尋關鍵字 benzoate and hydrazine 搜尋流程 首先前往 美國專利局網站( http://www.uspto.gov ) 點選 ( How To Search ) 點選 ( Search patents ) AppFT: Patent Applications PATFT: Issued Patents Quick Search Advanced Search Patent Number Search All Fields Claim(s) Abstract Title (7814)Iss (37)Iss (3)Iss (0)Iss PAT. NO. Inventor Company Filing Day Title Issued Day (Issued Patents) Group of a novel anti-cancer compounds with specific structure Yang; Zhenhua (West Covina, CA) Yang's Biochem Co. Ltd. (Diamond Bar, CA) August. 2, 2002年 October. 31, 2006年 7,129,366 October. 31, 1995年 March. 18, 1994年 5,462,714 Talwalker; Ramesh T. (Lexington, KY), Barve; Shirish S. (Lexington, KY) Arda Technologies (Lexington, KY) Antimicrobial composition and methods of use Eastman Kodak Company (Rochester, NY) August. 7, 1978年 June. 12, 1979年 4-(Hydrazonomethyl)benzoic acid hydrazide Musser; Harry R. (Kingsport, TN) 4,158,014 首先前往 中華民國專利資訊檢索系統( http://twpat1.tipo.gov.tw) 點選 ( 專利檢索) 輸入關鍵字查詢 查詢結果 列在Word及Excel表格內 申請案號 發明人 申請人 申請日 公告日 名稱 田京隼人 TAKYO, HAYATO井原秀樹 IHARA, HIDEKI 二唑化合物及其應用 住友化學股份有限公司 SUMITOMO CHEMICAL COMPANY, LIMITED日本 2007 09月03日 2008 07月01日 096132742

  2. 搜尋重要結果 7,129,366- (Issued Patents) 在動物實驗中,化合物中具有hydrazine基團,具有預防癌症的功能,包括皮膚癌,乳腺癌,前列腺癌,胃癌和肺癌等。 5,462,714- (Issued Patents) 做為抗菌劑使用,最好將pH值保持在pH值為3.0和5.0之間,而若能將pH值控制在3.8和4.2則是有最好的效果。 4,158,014- (Issued Patents) 由苯甲酸和hydrazine合成出的薄膜具有很好的抗張強度與撕裂強度。 心得與應用 從專利佈局中,讓我瞭解到原來我正在研究的領域,在生活上已有相當多的應用,大多都已應用在醫療上例如抗腫瘤、抗結核、抗過敏等等…也了解到許多人正在對這些衍生物做改良,所以這應是相當有發展潛力的新型抗菌劑。另外從專利佈局中也讓我查詢到正在研究或生產這些產品的公司以及發明人,我想對我未來踏入職場會有所幫助。 ACKNOWLEDGMENT 粘譽薰老師、王美心 老師。

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