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PNM July 2013

Maternal influenza vaccination targets two high-risk groups with one vaccine dose – pregnant mothers and newborn babies. PNM July 2013. Influenza in pregnancy. High morbidity and mortality for both baby and mum

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PNM July 2013

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  1. Maternal influenza vaccination targets two high-risk groups withone vaccine dose – pregnant mothers and newborn babies. PNM July 2013

  2. Influenza in pregnancy • High morbidity and mortality for both baby and mum • 2009-2010 pandemic showed that pregnant women were 7* more likely to be admitted to ICU than non pregnant women of the same age • and 20* more likely if >20/40 gestation (Aus & NZ data). Small number died. 5% worldwide data. • Immunosuppressed period places them at greater risk

  3. Influenza in pregnancy • Greatest risk in third trimester • Some data that cleft lips, NTD & CHD associated with influenza in pregnancy. • Rare trans placental influenza transmission • Indirect evidence that influenza associated with miscarriages, PTL, SGA and IUD

  4. Benefits • NNT 5: to prevent one case of serious maternal or infant respiratory illness • Prevents 1-2 hospitalisations per 1000 women vaccinated during T2/T3 • Provides protection to infants who are ineligible for vaccination until 6/12 of age

  5. Vaccine • Inactivated virus- therefore incapable of causing influenza. Preservative free (no mercury) • Available from March/April • Can be given at any gestation, IVF Rx or miscarriage Hx • Can be given at any time in the season, the earlier the better • Seroconversion at 4-6/52 after vaccination. Some maternal benefit at 2 weeks • No study has shown adverse consequences in mum or baby • Placental transfer of antibodies provides protection to infant for 6/12

  6. Endorsements • RANZCOG- if pregnant or planning to be pregnant during the flu season • Australian government • CDC • WHO- suggests pregnant women should be given the highest priority in seasonal vaccination • ACOG

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