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Sex determination

Sex determination. Jonathan Wolfe http://www.ucl.ac.uk/~ucbhjow. Objectives. At the end of this lecture you should: know in outline the developmental steps in human sex determination be able to describe the evolution of the mammalian Y chromosome and the SRY gene.

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Sex determination

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  1. Sex determination Jonathan Wolfe http://www.ucl.ac.uk/~ucbhjow

  2. Objectives At the end of this lecture you should: • know in outline the developmental steps in human sex determination • be able to describe the evolution of the mammalian Y chromosome and the SRY gene. • be able to describe the roles of the genes SRY, DAX1, and SOX9. • Be able to describe the genes involved in sex determination in Drosophila • Be able to describe the gene DMRT1 and its relatives

  3. Reading • http://www.hgmp.mrc.ac.uk/omim/searchomim.html Search here for any of the genes mentioned. • Goodfellow, P. N.; Lovell-Badge, R. 1993: SRY and sex determination in mammals. Ann. Rev. Genet. 27 71-92 • Koopman, P.; Gubbay, J.; Vivian, N.; Goodfellow, P.; Lovell-Badge, R. 1991: Male development of chromosomally female mice transgenic for Sry. Nature 351 117-121. • Wunderle, V. M.; et al. 1998: Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia. Proc. Nat. Acad. Sci. 95: 10649-10654. • Jennifer A. Marshall Graves 2002: The rise and fall of SRY Trends in Genetics 18: 259-264 • David Zarkower 2001 Establishing sexual dimorphism: conservation amidst diversity? Nature Reviews Genetics 2 175-185 • Peter Koopman and Kelly A. Loffler, 2003, Sex Determination: The Fishy Tale of Dmrt1 Current Biology, 13: R177 - R179 • Haag ES, Doty AV (2005) Sex Determination across Evolution: Connecting the Dots. PLoS Biol 3(1): e21

  4. Comparison between Drosophila and Humans

  5. Gonadal differentiation

  6. Y chromosomal genes

  7. Genomic structure of SRY genes

  8. Evolution of the Y chromosome and SRY

  9. The loss of Y chromosomal genes

  10. Sex determination in Drosophila

  11. Another human gene

  12. DMRT1 expression

  13. Chicken Z = Human chr.9

  14. DMRT1 expression in alligator

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