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Conclusions

Conclusions. Modulation of Mucosal Transmission Oral Poster Session. Session Theme: Focusing on identification of mucosal phenotypes associated with lower risk for HIV transmission (HEPS) & how to intervene?. Presentations….

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Conclusions

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  1. Conclusions Modulation of Mucosal Transmission Oral Poster Session

  2. Session Theme:Focusing on identification of mucosal phenotypes associated with lower risk for HIV transmission (HEPS)& how to intervene?

  3. Presentations….. • Female genital epithelial cells from HIV-exposed seronegative commercial sex workers express a discrete cytokine/chemokines profile upon toll-like receptor activation NylaDil, Canada • Inhibitory KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission WimJennes, Belgium • The dual role of genital RANTES in the spread of HIV infections Lenine Liebenberg, South Africa • Protein engineering of the lectinBanLecreduces its mitogenic activity and prevents vaginal HIV transmission Michael Swanson, United States • Characterization of a new use for acyclovir and tenofovirusing human cervico-vaginal tissue ex vivo Christophe Vanpouille, United States

  4. Questions… • Three of the presentations in this session highlighted the value of HEPS cohorts in understanding important translational targets for prevention research: • HEPS individuals tended to have lower inflammatory markers in genital secretions and lower production of important chemokines by epithelial cells following TLR stimulation • Two of the presentations explored microbicide and drug methods to block mucosal HIV transmisison • Lectins derived from plants could be formulated to block HIV tranmission in Humice; and combination drug therapy directed against HIV as well as common STIs (HSV-2)

  5. Comments… • Genital mucosal HIV transmission is dependent on a number of well described and less well understood co-factors (STIs, BV, hormone contraceptives, to name very few) which modulate the genital inflammatory environment to favour infection • HIV transmission risk and spread from the genital mucosa to systemic sites is dependent on an inflammatory environment (Li et al., 2009; Haase et al., 2010) • Modulation of mucosal transmission of HIV should include combination approaches aimed at managing common STI and/or associated inflammation/immune activation

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