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Akciğer Nakli: Tarihçe ve Genel Bakış

Akciğer Nakli: Tarihçe ve Genel Bakış. Dr. Levent Dalar Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi. Herhangi bir kişi ya da kurumla çıkar ilişkim ve çatışmam yoktur. Tarihçe. Öncüler İlk nakiller Kırılma noktaları Yenilikler. Genel Bakış. Neler değişti?

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Akciğer Nakli: Tarihçe ve Genel Bakış

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  1. Akciğer Nakli: Tarihçe ve Genel Bakış Dr. Levent Dalar Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi

  2. Herhangi bir kişi ya da kurumla çıkar ilişkim ve çatışmam yoktur.

  3. Tarihçe • Öncüler • İlk nakiller • Kırılma noktaları • Yenilikler

  4. Genel Bakış • Neler değişti? Endikasyonlar Teknikler • Sonuçlar • Sağkalım

  5. Öncüler: 1900’ler

  6. Öncüler: 1950’ler

  7. Neptune

  8. Öncüler: 1950’ler

  9. Öncüler: Marcus

  10. İlk Nakiller: Hardy

  11. İlk akciğer nakli hastası: J.R.

  12. 1963-1978 • Nakil denemeleri devam ediyor, yapılan 38 nakilin tamamı kaybediliyor. Sadece; 1969 Fritz Derom’un sağ AC nakli 10 ay yaşadı Derom F, Barbier F, Ringoir S. Ten month survival after lung homotransplantation in man J Thorac Cardiovasc Surg 1971; 61: 835-846

  13. Bruce Reitz ilk uzun yaşayan kalp akciğer naklini gerçekleştiriyor Reitz B, Wallwork J, Hunt S. N Eng J Med 1982; 306: 557

  14. Toronto 1983: Tom Hall

  15. Toronto 1986: İlk Bilateral Nakil

  16. REGISTRY DATABASE:Number of Transplants Reported ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  17. REGISTRY DATABASE:Number of Centers Reporting Lung Transplants ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  18. REGISTRY DATABASE:Number of Centers Reporting Lung Transplants ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  19. NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as representing changes in the number of lung transplants performed worldwide. 2011

  20. AVERAGE CENTER VOLUMELung Transplants: January 1, 2000 - June 30, 2010 ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  21. LUNG TRANSPLANTS:Transplant Recipient Age by Year of TransplantTransplants: January 1, 1987 – June 30, 2010 ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  22. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS (1/1985-6/2010) ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  23. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 Transplants with unknown recipient age were excluded from this tabulation. 2011

  24. LUNG TRANSPLANTS: Donor Age by Year of Transplant Transplants: January 1, 1987 – June 30, 2010 ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  25. AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  26. AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  27. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival (Transplants: January 1994 - June 2009) ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  28. ADULT LUNG TRANSPLANTATION: Indications for Single Lung Transplants (Transplants: January 1995 - June 2010) ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 *Other includes: Pulmonary Fibrosis, Other: 3.4% Sarcoidosis: 1.9% Bronchiectasis: 0.4% Congenital Heart Disease: 0.3% LAM: 0.8% Connective Tissue Disease: 1.0% OB (non-ReTx): 0.6% Miscellaneous: 0.9% 2011

  29. ADULT LUNG TRANSPLANTATION: Indications for Bilateral/Double Lung Transplants (Transplants: January 1995 - June 2010) ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 *Other includes: Pulmonary Fibrosis, Other: 2.9% Sarcoidosis: 3.0% Bronchiectasis: 4.4% Congenital Heart Disease: 1.2% LAM: 1.1% Connective Tissue Disease: 1.3% OB (non-ReTx): 1.3% Miscellaneous: 1.7% 2011

  30. ADULT LUNG TRANSPLANTATIONMajor Indications By Year (Number) ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  31. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2009) ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  32. ADULT LUNG TRANSPLANTS (1997-6/2009)Risk Factors for 1 Year Mortality ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 (N=13,937) 2011

  33. ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 ADULT LUNG TRANSPLANTS (1997-6/2009)Borderline Significant Risk Factors for 1 Year Mortality (N=13,937) Reference group = COPD/Emphysema, Single lung *Other = All diagnoses other than COPD, IPAH, IPF, cystic fibrosis, pulmonary fibrosis,bronchiectasis,alpha-1 antitrypsin deficiency, retransplant and LAM. 2011

  34. ADULT LUNG TRANSPLANTS(1/1997-6/2009)Risk Factors for 1 Year Mortality ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  35. ADULT LUNG RECIPIENTSCross-Sectional AnalysisFunctional Status of Surviving Recipients(Follow-ups: April 1994 – June 2010) ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

  36. ADULT LUNG TRANSPLANT RECIPIENTS: Relative Incidence of Leading Causes of Death(Deaths: January 1992 - June 2010) ISHLT ISHLT J Heart Lung Transplant. 2011 Oct; 30 (10): 1071-1132 2011

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