1 / 35

Influenza clinical features epidemiology dd. Sonbol Taramian MD inf.dis.department GUMS

Influenza clinical features epidemiology dd. Sonbol Taramian MD inf.dis.department GUMS. All age groups but some, more at risk !.

wandag
Download Presentation

Influenza clinical features epidemiology dd. Sonbol Taramian MD inf.dis.department GUMS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Influenzaclinical featuresepidemiologydd.SonbolTaramian MDinf.dis.departmentGUMS

  2. All age groupsbut some,moreat risk!

  3. pregnant women, children < 59 mths,the elderly, chronic medical conditions(chronic cardiac, pulmonary, renal, metabolic, neurodevelopmental, liver or hematologic dis.) IC:(HIV/AIDS, chemotherapy or steroids, or malignancy)HCW

  4. Changes in immune system, heart, and lungs during pregnancy (and up to 2 wks postpartum) more prone to severe illness from flu, including illness resulting in hospitalization

  5. changes include :elevation of diaphragm to accommodate the uterus, increased respiratory rate, increased intra‐abdominal pressure, decreased chest compliance,and as a consequence,increased risk of aspiration

  6. Pregnancy has been considered an an immunosuppressive state

  7. The pathophysiologic mechanisms underlying increased flu risk to pregnant women and their fetuses are unclear

  8. Replication of flu v. is significantly higher in peripheral blood mononuclear cells (PBMCs) incubated with 3rd trimester serum

  9. rapidtransmissionin crowded areas (schools / nursing homes)coughs or sneezes, in closeproximityby contaminated hands

  10. Adults spread from 1 d. before symptoms to5 d. afterChildren and IC, longer

  11. incubation period: about 2 d.(1-4d.)

  12. timing of flu is very unpredictable

  13. mild to severe illnessfromasymptomatic tomild, uncomplicated tosevere, complicated illness

  14. typical symptoms sudden onset of:high fevermuscle achesheadachechillsfatigueloss of appetitesore throatIn some,especially children, nausea, vomiting and diarrhea

  15. Flu ComplicationsMost , recoverin a few d. to <2 wks

  16. moderate complications: Sinus and ear inf.

  17. pneumoniaa serious complication from flu v. infaloneor co-inf with bac.

  18. Other possible serious complicationstriggered by flu :myocarditis,encephalitis ormyositis, rhabdomyolysis, and multi-organ failure

  19. most , recover in 7 - 10 d.,severe illness can occurv. can triggeran extreme inflammatory response and lead to sepsis

  20. worse chronic medical problems asthma, chronic heart dis.

  21. Difficulty breathing orshortness of breathPain or pressure in the chest or abd.Sudden dizzinessConfusionSevere or persistent vomiting

  22. Flu-like symptoms improve but then return withfever and worse cough

  23. Almost all of   flu v. examined this season are still similar to the cell-grown vaccine reference v.( not significant Agicdrift)

  24. How commonly mismatch occurs between flu vaccine strains and circulating flu v.?

  25. 17 years' of data ,close match only 11% - 21% of time1996 - 2012, 17-yr period divided into 34 flu seasons—winter and summer for each yr.:Northern Hemisphere vaccine strains :closely matched with circulating strains for 7 (20.6%) of 34 seasons for H3N2 and 5 (14.7%) of 34 seasons for flu B. For the Southern Hemisphere vaccine, rates were 14.7% for H3N2 and 11.1% for flu B.Strain drift among seasons: 41.2% for H3N2 and 35.3% for influenza B

  26. In recent yrs multiple novel flu A strains have emerged in humans

  27. MostzoonoticAIVs and swine flu variants typically cause mild inf. in humans however severe illness and fatalities are associated with zoonotic H5N6, H10N8, H7N9 and H5N1 serotypes, and H1N1 1918 Spanish flu.

  28. changing landscape of avian flu globally indicates a need to reassess the risk of a pandemic flu outbreak of zoonotic origin

  29. an increase in emergence of AIVs infecting humans in the last decade (i) improvements in zoonotic AIV case ascertainment,

  30. (ii) a “true” increase in AIV emergence,

  31. which could be explained by an increase in AIV circulation and diversity in poultry populations, growths in the poultry industry

  32. not any reports of AIV emergence in humans in low-income, developing countries – this may also be due to case ascertainment bias. Developing countries are both unable to support high levels of active AIV surveillance (in both human and animal sectors), and highly regulated agricultural systems with the ability to enforce dis. control regulations

  33. Avian flu has the highest case-fatality rate among 10-39 yrs. Unlike seasonal flu, (very young and very old individuals),young adults a large proportion of avian flu cases50%,<20 yrs. 40%,aged 20-40 yrsIn Egypt, avian flu ,a relatively low mortality rate, associated with a high rate of inf. in young children (< 10 y); as of May 2009, the mortality rate in this subpopulation has been zeroThe significance and reproducibility of these findings remains to be seen

  34. Infectious diseases causing ILI: malaria, acute HIV/AIDS inf., hepatitis C, Q fever,dengue fever,pneumonia, Pharmaceutical drugs :biologics such as IFN and monoclonal Abs, CSFsChemotherapeutic agentsbisphosphonates, caspofungin, and levamisoleinfluenza vaccine or other vac., opioid withdrawal in addicts

  35. rhinoviruses,coronaviruses, human respiratory syncytial virus, adenoviruses,human parainfluenza v. Less common causes bacegLegionella, Chlamydia pneumoniae, Mycoplasmapneumoniae, and Streptococcus pneumoniae. RSV

More Related