1 / 3

Jack K. Horner Science Applications International Corporation P. O. Box 3827 Santa Fe, NM 87501

A Phylogenetic Method for Identifying a Stage I Ovarian Cancer Signature in the Mass-Spectrum of Serum Proteins. Jack K. Horner Science Applications International Corporation P. O. Box 3827 Santa Fe, NM 87501 Email: jack.k.horner@saic.com. Problem and Method.

Download Presentation

Jack K. Horner Science Applications International Corporation P. O. Box 3827 Santa Fe, NM 87501

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. A Phylogenetic Method for Identifying a Stage I Ovarian Cancer Signature in the Mass-Spectrum of Serum Proteins Jack K. Horner Science Applications International Corporation P. O. Box 3827 Santa Fe, NM 87501 Email: jack.k.horner@saic.com A Phylogenetic ...

  2. Problem and Method • Problem: ovarian cancer (OC) can currently be diagnosed only at advanced stages, when prognosis is very poor • Objective: find a method that detects OC at a stage at which it can be successfully treated • Method (using serum protein mass-spectra) • form a set of known cancer, and known non-cancer, spectra; call this the “reference” set • merge reference set with unknown spectrum U • apply the phylogenetic maximum parsimony method to the merged set • declare U to have the same disease state as its siblings in the tree A Phylogenetic ...

  3. Results (How well does the method work?) Correct classification rate 133 known cancer, and 95 known non-cancer, spectra ~370,000 points per spectrum Phylogenetic Analysis Using Parsimony (Ver. 4.0b10) MP heuristic search, seed from clock, 31 runs Mean .893 Std Err .003 Kurtosis -.297 Median .890 Std Dev .017 S.E. Kurt. .880 Mode .890 Variance .000 Skewness .150 Minimum .860 Sum 27.670 S.E. Skew. .440 Maximum .930 Range .070 Valid 31.000 95% Confidence Interval for the mean = [.8862 to .8989] A Phylogenetic ...

More Related