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Controlled ion transport via organic ion channel mimics

Controlled ion transport via organic ion channel mimics. Blocked ion flow. Ion flow. X. Signal. Phospholipid Bilayer Membrane. Channel Components. macrocycle template for various pore sizes. = alkyl chains of different lengths favor membrane insertion.

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Controlled ion transport via organic ion channel mimics

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  1. Controlled ion transport via organic ion channel mimics Blocked ion flow Ion flow X Signal Phospholipid Bilayer Membrane

  2. Channel Components macrocycle template for various pore sizes = alkyl chains of different lengths favor membrane insertion = polar oligoether chains allow ions to traverse through the channel

  3. Initial gates under investigation

  4. Testing of Gated Ion Transport Channel M+ M+ Small unilamellar vesicle M+ M+ H+ M+ M+ M+ M+ M+ H+ M+ M+ H+ Signal M+ H+ M+ M+ Concentration gradient maintained Ion transport detected by fluorescence

  5. Participation in AMWP will direct application development Macrocycle size and composition can be altered for selective transport of different ions Channel gate can be chosen based on the best signal for opening Chain length and functionality can be modified for incorporation in artificial support membranes

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