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PLANT POISONS

PLANT POISONS. Every thing is poisonous, only the amount differentiates a poison from a remedy. Types of Poisoning. Accidental Intentional-Suicidal, Medicinal Raw plant, tea made from the plant. Mechanisms. Toxic to CVS: e.g oleander CNS:e.g Datura Blood: e.g Abrus

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PLANT POISONS

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  1. PLANT POISONS

  2. Every thing is poisonous, only the amount differentiates a poison from a remedy.

  3. Types of Poisoning Accidental Intentional-Suicidal, Medicinal Raw plant, tea made from the plant

  4. Mechanisms Toxic to CVS: e.g oleander CNS:e.g Datura Blood: e.g Abrus Liver: e.g Mushrooms Kidney:e.g Cleistanthus

  5. General issues Proper identification of plant is key to prognosis, therapy and preventing unnecessary treatment Majority of plant poisoning needs supportive management

  6. Treatment Terminating further exposure Dilution with cool fluids may relieve irritating sensation or disagreeable taste Gentle cleansing with soap and water in peri oral and dermal exposures No role for induced emesis with ipecac Gastric lavage Role of activated charcoal No role for cathartics and whole bowel irrigation

  7. CARDIOVASCULAR TOXINS Thevetia nerifolia-yellow oleander Nerium oleander-pink oleander Digitalis purpurae Digitalis lanata Cleistanthus collinus-oduvanthalai Poisoning calotropis

  8. OLEANDER

  9. OLEANDER SEEDS

  10. PINK OLEANDER

  11. OLEANDER POISONING All parts of the plant are poisonous. Peruvoside, cerebrin and thevetin –active components. Ingestion of more than 2 seeds is toxic. as seeds contain more glycosides than other parts

  12. MECHANISM OF TOXICITY Inhibition of Na+/K+-ATPase pump leading to overall increase in intracellular Na+ ions and secondary increase in intracellular Ca+ levels Partly vagotonic action SA node, AV node and conduction system are involved. Form of focal toxic myocarditis [Lymphocyte infiltration of the conduction system]

  13. CLINICAL FEATURES On ingestion ,burning sensation, abdominal pain nausea ,vomiting ,diarrhea ,also dizziness and numbness in oral and perioral region Most important cardio toxic effects are sinus bradycardia, varying degrees of heart block, ventricular ectopics, ventricular tachycardia which can be fatal.

  14. INCIDENCE OF HEART BLOCK IN GGH

  15. Acute hemolysis occurs due to inhalation of oleander blossoms. Dermal route of exposure can cause local irritation and inflammation, unconsciousness and convulsions . Hyperkalemia occurs due to acute toxicity. Hypoxia and metabolic acidosis are potential complications

  16. MONITORING Rate Pulse rate E.C.G Serum potassium Blood urea Serum creatinine Arterial blood gas analysis

  17. MANAGEMENT If patient arrives within 4 hrs of ingestion, and the patient has no convulsions and fully conscious, perform gastric lavage. Take care of ABC and stabilize Activated charcoal and cholestyramine to decrease absorption. Treatment of hyperkalemia and arrhythmias Fab fragments

  18. MANAGEMENT OF CARDIOTOXICITY Atropine 0.6 mg ,Orciprenaline 10mg to maintain HR around 80/mt. T-wave inversion and ST depression due to toxic myocarditis corrected over a period of 3-4 hrs with the above regimen. Sodium bicarbonate 50 ml iv 6th hourly if ABG shows acidosis.

  19. Monitor heart rhythm for at least 5 days. If the heart rate persists below 30/mt after all these regimen put the patient on temporary pacemaker. Do not treat asymptomatic Ventricular premature beats, if symptomatic use lignocaine 1mg/kg iv every 5-10 minutes.

  20. . Forced alkaline diuresis has no role in the management . Peritoneal dialysis, hemodialysis, hemoperfusion do not increase the elimination of cardiac glycosides because of large volume of distribution

  21. ODUVANTHALAI POISONING Cleistanthus collinus Second most common suicidal plant poison in rural south India after oleander poisoning. Poison preferred by young women.

  22. Pathogenesis Cleistanthus collinus is an extremely toxic plant poison. It is known by various names in different parts of India viz., Oduvanthalai / Nillipalai in Tamilnadu and Pondicherry, Kadishe in Andhra pradesh, Karlajuri in West Bengal and Garari in the Hindi speaking belt. All parts of the plant are poisonous. Cleistanthin A and B are the toxins of Cleistanthus collinus They are diphyllin glycosides which produce cardiac arrhythmias, urinary potassium wasting, hypoxia, metabolic acidosis and hypotension.

  23. MECHANISM OF TOXICITY Inhibition of Na+K+ATPase The cause of hypokalemia remains enigmatic.

  24. Pathogenesis Hypokalemic metabolic acidosis, hypotension and hypoxia have been described in this poisoning. Cases have been reported where dRTA, distributive shock and ARDS identified in patients, explaining the above findings

  25. CLINICAL FEATURES ECG abnormalities :Bradycardia, Varying degrees of heart Blocks Hypokalemia : Severe hypokalaemia Severe non anion gap metabolic acidosis Increased urinary K+ excretion Increased urine anion gap

  26. MONITIORING E.C.G Serum potassium Heart rate Blood pressure Respiratory rate QTc –USEFUL PROGNOSTIC INDEX

  27. Management Correct hypokalemia by i.v KCL AT A RATE OF NOT MORE THAN 40 meq/l Bradycardia corrected with atropine 0. 6mg/Orciprenaline 10mg. If the heart rate is less than 30/mt, temporary Trans venous pacing may be instituted

  28. Calotropis Calotropis is used as a traditional medicinal plant with unique properties Traditionally alotropis is used alone or with other medicinals to treat common disease such as fevers, rheumatism, indigestion, cough, cold, eczema, asthma, elephantiasis, nausea, vomiting, diarrhea According to Ayurveda, dried whole plant is a good tonic, expectorant,, and anthelmintic. The dried root bark is a substitute for ipecacuanha. The powdered root used in asthama, bronchitis, and dyspepsia.

  29. Calotropis

  30. Toxicity Signs Acrid taste usually limits ingestion. Exposure of the skin or mucous membranes to the latex may result in vesicle formation. Keratoconjunctivitis will result if the cornea is exposed. Ingestion of significant quantities will result in ECG abnormalities.

  31. Treatment Wash the exposed tissue with plenty of warm water and soap. Flush the eyes with sterile saline or water for 15 minutes. If cardiac abnormalities are seen, manage according to ECG assessment

  32. AUTONOMIC NERVOUS SYSTEM TOXINS DATURA STRAMONIUM ATROPA BELLADONA HYOSCYAMUS NIGER

  33. DATURA STRAMONIUM All parts of the plant are poisonous. Seeds are considered to be the most noxious. The alkaloids are scopalamine and hyoscyamine or atropine both have anticholinergic effects. Mostly accidental ingestion by children. Also used to induce hallucinations. Contact with leaves/flowers-dermatitis

  34. Fruit containing the Seed

  35. DATURA PERIPHERAL ANTICHOLINERGIC CENTRAL ANTICHOLINERGIC CLINICAL FEATURES

  36. PERIPHERAL ANTICHOLINERGIC Tachycardia Dry flushed skin Dilated pupils Hyperpyrexia Urinary retention Hypertension/hypotension

  37. CENTRAL ANTICHOLINERGIC Disorientation Agitation Muscle in coordination Ataxia Visual/auditory hallucinations Severe toxicity can result in seizures, respiratory Failure & cardiovascular collapse.

  38. Investigations Detection of Atropine by Radio immuno assay Gas chromatography Mass spectrometry Thin layer chromatography Liquid chromatography

  39. MANAGEMENT Supportive care Airway Circulation Gastric lavage (due to inhibition of peristalsis, seeds may remain in stomach for up to 24 hrs). Activated charcoal-50g every 4 hrs and magnesium sulphate 30g every 4 hrs

  40. MANAGEMENT Hypotension: IVF, Dopamine Convulsions & agitation: :IV Diazepam 10 -20mg over 30-60minutes not to exceed 3mg/kg over 24hrs Not to use chlorpromazine for controlling agitation, Hyperactivity, disorientation Severe Hyperthermia: Sedation, Paralysis and active cooling Careful use of physostigmine to counteract CNS anticholinergic syndrome.

  41. PHYSOSTIGMINE USE To be used only if definitely known Dosage: 1-2 mg IV slowly repeated every 10 min. should not exceed 4 mg in 30 min period Watch for seizure activity, bradycardia, heart blocks, and asystole

  42. INDICATIONS OF PHYSOSTIGMINE Pronounced hallucinations and agitation Supraventricular arrthymias and ventricular arrthymias with hemo dynamic instability Seizures unresponsive to standard anticonvulsants

  43. Toxalbumins (Ricin, Abrin) Both differ in appearance and taxonomy but both toxins are similar structurally and functionally Synonyms: Ricinus communis: castor bean Abrus: jequirity, Indian bead, rosaeary pea Toxic parts: All parts especially seeds

  44. Abrus -Seeds

  45. Ricinus Plant

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