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PhD Students: Robert Arnell Jörgen Samuelsson Group Leader: Torgny Fornstedt

Separation Science – Uppsala University RESEARCH In the Border Between Analytical Chemistry, Physical Chemistry and Chemical Engineering. PhD Students: Robert Arnell Jörgen Samuelsson Group Leader: Torgny Fornstedt Torgny.Fornstedt@ytbioteknik.uu.se 070-425 06 83. Research Profile.

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PhD Students: Robert Arnell Jörgen Samuelsson Group Leader: Torgny Fornstedt

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  1. Separation Science – Uppsala UniversityRESEARCH In the Border Between Analytical Chemistry, Physical Chemistry and Chemical Engineering PhD Students: Robert Arnell Jörgen Samuelsson Group Leader: Torgny Fornstedt Torgny.Fornstedt@ytbioteknik.uu.se 070-425 06 83

  2. Research Profile • Preparative LC Theory • Computer Simulations • New Methods for Determination of Adsorption Isotherms • Characterization of New Columns (Adsorption Energy Distribution calculations) • Preparative CSPs • HPLC Phases for Alkaline Conditions • Tuning of Band Shapes for Increased Production (Chirobiotic T, CHI-TBB?) a

  3. Why measure Adsorption Isotherms? • 1. Analytical Reason: • A. Column Characterization • Capacity, Selectivity • Surface Heterogeneity • B. Detailed Characterization of Drug-Protein Interactions using Immobilized Protein Stationary Phases • Affinity, Enantioselectivity • Displacement Studies • Multi-Site Interaction

  4. Why measure Adsorption Isotherms? • 2. Process Related Reason: Adsorption Isotherms Known Chromatography Simulation Numerical Process Optimization (SMB)

  5. Publications 2006 • An Improved Algorithm for Solving Inverse Problems in Liquid Chromatography.P. Forssén, R. Arnell and T. Fornstedt. Computers & Chemical Engineering (2006) 30, 1381-1391. • 2. Discovery of invisible extra fronts in single-component frontal analysis in liquid chromatography by J. Samuelsson and T. Fornstedt. Journal of Chromatography A (2006) 1114, 53-61. • 3. Analytical Characterization of Chiral Drug-Protein Interactions: Comparison between an SPR Assay and the HPLC Perturbation Method.R. Arnell, N, Ferraz and T. Fornstedt. Analytical Chemistry (2006) 78 1682-1689. • 4. Invisible Analyte Peak Deformations in Single-Component Liquid Chromatography” by J. Samuelsson, R. Arnell and T. Fornstedt. Analytical Chemistry (2006) 78 2765-2771. • 5. Validation of the Tracer Pulse Method for Multi Component Liquid Chromatography- a Classical Paradox Revisited. R. Arnell and T. Fornstedt. Analytical Chemistry (2006) 78, 4615-4623. • 6. General theory of indirect detection in chromatography.P. Forssén and T. Fornstedt. Journal of Chromatography A (2006) 1126, 268-275.

  6. OUR GROUP! • Patrik Forssén • Dept. Of Scientific Computing • From left: Robert Arnell, Jörgen Samuelsson and T. Fornstedt Se vår kurs industrin: HPLC teori för praktiskt bruk, Flera tillfällen tidigt i vår, kommer upp snart på: http://www.kemi.uu.se/industrikurser/LC-teori/index.shtm

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