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Ombitasvir-Paritaprevir - Ritonavir and Dasabuvir + RBV in GT1 SAPPHIRE-II

Phase 3. Treatment Experienced. Ombitasvir-Paritaprevir - Ritonavir and Dasabuvir + RBV in GT1 SAPPHIRE-II. Zeuzem S, et al. N Engl J Med. 2014;370:1604-14. Ombitasvir-Paritaprevir - Ritonavir and Dasabuvir + RBV in GT1 SAPPHIRE -II: Study Design.

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Ombitasvir-Paritaprevir - Ritonavir and Dasabuvir + RBV in GT1 SAPPHIRE-II

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  1. Phase 3 TreatmentExperienced Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir + RBV in GT1SAPPHIRE-II Zeuzem S, et al. N Engl J Med. 2014;370:1604-14.

  2. Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir + RBV in GT1SAPPHIRE-II: Study Design Source: Zeuzem S, et al. N Engl J Med. 2014;370:1604-14.

  3. Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir + RBV in GT1SAPPHIRE-II: Regimens 0 12 24 36 Week Double blind Ombitasvir-Paritaprevir-RTV and Dasabuvir + Ribavirin Active N = 297 SVR12 Open label (data pending) Placebo Ombitasvir-Paritaprevir-RTV and Dasabuvir + Ribavirin PlaceboN = 97 SVR12 RTV = Ritonavir Drug DosingOmbitasvir-Paritaprevir-Ritonavir (25/150/100 mg once daily)+ Dasabuvir: 250 mg twice dailyRibavirin (RBV): weight-based and divided bid (1000 mg/day if < 75kg or 1200 mg/day if ≥ 75kg) Source: Zeuzem S, et al. N Engl J Med. 2014;370:1604-14.

  4. Ombitasvir-Paritaprevir-Ritonavir + Dasabuvir + RBV in GT1SAPPHIRE-II Study: Baseline Characteristics Source: Zeuzem S, et al. N Engl J Med. 2014;370:1604-14.

  5. Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir + RBV in GT1SAPPHIRE-II: Results SAPPHIRE-II: Results by Genotype 1 Subtype 286/297 166/173 119/123 Source: Zeuzem S, et al. N Engl J Med. 2014;370:1604-14.

  6. Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir + RBV in GT1SAPPHIRE-II: Results SAPPHIRE-II: Results by Prior Treatment Response 286/297 82/86 65/65 139/146 Source: Zeuzem S, et al. N Engl J Med. 2014;370:1604-14.

  7. Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir + RBV in GT1SAPPHIRE-II Study: Key Adverse Events Source: Zeuzem S, et al. N Engl J Med. 2014;370:1604-14.

  8. Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir + RBV in GT1SAPPHIRE-II: Conclusions Source: Zeuzem S, et al. N Engl J Med. 2014;370:1604-14.

  9. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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