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bioorganuli qimiis laboratoria

bioorganuli qimiis laboratoria. laboratoriuli samuSao #1. monosaqaridebis anomeruli formebis gamoyofa. monosaqaridebis cikluri formebi warmoadgenen ciklur naxevaracetalebs, romlebic miiReba martivi naxSirwylebis molekulaSi spirtuli da karboniluri jgufebis Sigamolekuluri ciklizaciiT.

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bioorganuli qimiis laboratoria

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  1. bioorganuli qimiis laboratoria laboratoriuli samuSao #1

  2. monosaqaridebis anomeruli formebis gamoyofa

  3. monosaqaridebis cikluri formebi warmoadgenen ciklur naxevaracetalebs, romlebic miiReba martivi naxSirwylebis molekulaSi spirtuli da karboniluri jgufebis Sigamolekuluri ciklizaciiT. Sigamolekuluri urTierTqmedebis Sedegad warmoiqmneba Termodinamikurad SedarebiT mdgradi xuTwevriani (furanozuli) da eqvswevriani (piranozuli)formebi. ciklur formaSi damatebiT Cndeba erTi xiraluri (asimetriuli) naxSirbadis atomi, romelsac ewodeba anomeruli naxSirbadi, xolo am anomeruli atomiT gamowveul stereoizomerul modifikaciebs _ - da -anomerebi.

  4. myar mdgomareobaSi monosaqaridebi imyofeba ciklur formaSi. imis mixedviT, Tu romeli gamxsneliT gadavakristalebT maT, miiReba - an -forma. magaliTad, spirtis an civi ZmarmJavas gamoyenebiT glukoza xsnaridan -formis saxiT gamoiyofa, xolo piridinis an cxeli ZmarmJavas gamoyenebiT _ -formis saxiT. -forma SedarebiT cudad ixsneba wyalSi, vidre -forma. isini erTmaneTisagan gansxvavdebian xvedriTi brunvis sididiT (-anomeri polarizaciis sibrtyes abrunebs +112,20-iT, xolo -anomeri - +190-iT. axladdamzadebuli TiToeuli anomeris xsnarSi SeiniSneba xvedriTi brunvis cvlileba mudmivi sididis (+52,50) miRebamde. es movlena (mutarotacia) aRmoCenil iqna 1846 w. am dros erTi cikluri forma dayovnebisas RiajaWviani formis gavliT gadadis meore ciklur formaSi. garkveuli drois Semdeg maT Soris myardeba wonasworuli Tanafardoba.

  5. -D_glukopiranoza

  6. reaqtivebi:D-glukoza, yinulovani ZmarmJava, spirti. xelsawyoebi da sareaqcio WurWeli: qimiuri Wiqa, minis wkiri, pipeti, gamzomi cilindri, biuxneris Zabri, wylis abazana.

  7. 2,5ml cxel wyalSi (wylis abazana) xsnian 5g D-glukozas. qimiur Wiqas gadmodgamen wylis abazanidan da umateben 10 ml civ yinulovan ZmarmJavas. TandaTan warmoiqmneba uwylo -D-glukopiranozis kristalebi, romelsac filtraven biuxneris Zabrze da recxaven spirtiT. gamosavlianoba 4g (80%). []D +110 (wyali).literatura:Hudson C., Dale G. J. Am. Chem. Soc., 1917, 39, 320

  8. β-D_glukopiranoza

  9. reaqtivebi:D-glukoza, yinulovani ZmarmJava, spirti. xelsawyoebi da sareaqcio WurWe­li:qimiuri Wiqa, minis wkiri, mrgvalZira kolba, gamzomi cilindri, ukumacivari, biuxneris Zabri, wylis abazana.

  10. 5g D-glukozisa da 10ml wylis narevs acxeleben wylis abazanaze glukozis gaxsnamde. Semdeg umateben winaswar 100C_mde gacxelebul 6ml yinulovan ZmarmJavas. morevis pirobebSi produqti swrafad kristaldeba, romelsac filtraven biuxneris Zabrze. miRebuli nivTiereba Seicavs daaxloebiT 93% -formas. []D +24,5 (wyali).literatura: Hudson C., Dale G. J. Am. Chem. Soc., 1917, 39, 320.

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