Dup15q Syndrome Prevalent Cases and Report Perspective

1. Dup15q Syndrome Prevalent Cases and Report Perspective telegra.ph/Dup15q-Syndrome-Prevalent-Cases-and-Report-Perspective-04-08 consulting services April 8, 2021 dup15q Dup15q syndrome is a neurogenetic disorder that results from duplications of chromosome 15q11.2-13.1. It is characterized by hypotonia, developmental delay and intellectual disability (ID), epilepsy, and autism spectrum disorder (ASD). However, the severity of developmental disabilities can vary widely depending on the type of duplication that occurred and whether it was derived maternally or paternally. Children with 15q11-q13 duplications are at high risk for neurodevelopmental disabilities, particularly autism spectrum disorder (ASD) and intellectual disability (ID).Currently, there are no specific treatments for dup15q syndrome; however, there are therapies available to address specific symptoms associated with the condition, such as antiepileptic medications, physical, occupational, and speech therapy, and applied behavioral analysis (ABA) therapy to treat social skill deficits associated with autism spectrum disorders. The market is expected to grow by factors like an increase in the patient pool, expected entry of emerging therapy, i.e., Soticlestat (OV935/TAK-935), and deeper penetration in the 7MM markets. The total prevalent population of Dup15q syndrome in the 7MM was 46,259 in 2020. As per estimates, the US had the highest diagnosed prevalence of Dup15q syndrome, and among the EU5, Germany had the highest diagnosed prevalent population, followed by the United Kingdom and Italy in 2020. Based on the mechanism of action of duplication, 1/2

2. Dup15q syndrome is categorized into two types, i.e., isodicentric 15 chromosome [idic(15)] and interstitial duplication 15 [int dup(15)]. Idic(15) is found in the majority of cases, wherein the individuals with Idic (15) have an extra chromosome formed due to a duplicated and inverted portion of chromosome 15. Besides, in int dup (15), a section of the q arm of chromosome 15 gets duplicated. The Dup15q syndrome market size in the 7MM was USD 17.28 million in 2020.According to the estimates, the highest market size of Dup15q syndrome was found in the United States, followed by Japan. The market size of United States in 2020 was found to be USD 9.84 million, and the market size of Japan was USD 2.63 million. 2/2